Library Science

Expert researchers and physicians not only describe classic and contemporary laboratory methods for studying tissue repair using a broad range of wound healing models, but also provide sensitive assays for the assessment of tissue healing. The systems detailed include human, animal, in vitro, in vivo, and impaired healing models, as well as models in which underlying systemic and genetic conditions influence the healing process. These powerful models illustrate the biochemical, molecular, and surgical techniques designed for the analysis and manipulation of the healing wound, and provide step-by-step instructions to ensure robust results.

Authors: DiPietro, Luisa A. ; Burns, Aime L.

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Table of Contents

1. Excisional Wound Healing: An Experimental Approach (pp. 003-015)
   Frank, Stefan; Kampfer, Heiko
2. Methods in Reepithelialization: A Porcine Model of Partial-Thickness Wounds (pp. 017-036)
   Paddock, Heather N.; Schultz, Gregory S.; Mast, Bruce A.
3. Incisional Wound Healing: Model and Analysis of Wound Breaking Strength (pp. 037-054)
   Gamelli, Richard L.; He, Li-Ke
4. Animal Models of Ischemic Wound Healing: Toward an Approximation of Human Chronic Cutaneous Ulcers in Rabbit and Rat (pp. 055-065)
   Sisco, Mark; Mustoe, Thomas A.
5. Corneal Injury: A Relatively Pure Model of Stromal-Epithelial Interactions in Wound Healing (pp. 067-081)
   Wilson, Steven E.; Mohan, Rahul R.; Ambrosio, Renato; Mohan, Rajiv R.
6. Subcutaneous Sponge Models (pp. 083-093)
   Efron, David T.; Barbul, Adrian
7. A Mouse Model of Burn Wounding and Sepsis (pp. 95-106)
   Stevenson, Julia M.; Gamelli, Richard L.; Shankar, Ravi
8. A Porcine Burn Model (pp. 107-120)
   Singer, Adam J.; McClain, Steve A.
9. Wound Healing in Airways In Vivo (pp. 121-132)
   White, Steven R.
10. Murine Models of Intestinal Anastomoses (pp. 133-140)
    Williams, David L.; Browder, I. William
11. Murine Model of Peritoneal Adhesion Formation (pp. 141-148)
    Jahoda, Andrew E.; Olson, Mary Kay; Kovacs, Elizabeth J.
12. Methods for Investigating Fetal Tissue Repair (pp. 149-160)
    Peled, Ziv M.; Warren, Stephen M.; Bouletreau, Pierre J.; Longaker, Michael T.
13. Growth of Human Blood Vessels in Severe Combined Immunodefi cient Mice: A New In Vivo Model System of Angiogenesis (pp. 161-178)
    Polverini, Peter J.; Nor, Jacques E.; Peters, Martin C.; Mooney, David J.
14. Tissue Repair in Models of Diabetes Mellitus: A Review (pp. 181-190)
    Greenhalgh, David G.
15. Wound Healing Studies in Transgenic and Knockout Mice: A Review (pp. 191-216)
    Grose, Richard; Werner, Sabine
16. Wound Repair in Aging: A Review (pp. 217-238)
    Reed, May J.; Koike, Teruhiko; Puolakkainen, Pauli
17. Specimen Collection and Analysis: Burn Wounds (pp. 241-254)
    Kowal-Vern, Areta; Latenser, Barbara A.
18. Suction Blister Model of Wound Healing (pp. 255-262)
    Koivukangas, Vesa; Oikarinen, Aarne
19. Implantable Wound Healing Models and the Determination of Subcutaneous Collagen Deposition in Expanded Polytetrafl uoroethylene Implants (pp. 263-274)
    Jorgensen, Lars Nannestad; Madsen, Soren Munk; Gottrup, Finn
20. The Fibroblast-Populated Collagen Lattice: A Model of Fibroblast Collagen Interactions in Repair (pp. 277-292)
    Ehrlich, H. Paul
21. A Quantifi able In Vitro Model to Assess Effects of PAI-1 Gene Targeting on Epithelial Cell Motility (pp. 293-304)
    Providence, Kirwin M.; Staiano-Coico, Lisa; Higgins, Paul J.
22. Human Skin Organ Culture (pp. 305-310)
    Moll, Ingrid
23. In Vitro Matrigel Angiogenesis Model (pp. 311-316)
    Szpaderska, Anna M.; DiPietro, Luisa A.
24. Quantifi cation of Wound Angiogenesis (pp. 319-328)
    Low, Quentin E. H.; DiPietro, Luisa A.
25. In Vivo Matrigel Migration and Angiogenesis Assays (pp. 329-336)
    Malinda, Katherine M.
26. Endothelial Cell Migration Assay: A Quantitative Assay for Prediction of In Vivo Biology (pp. 337-348)
    Lingen, Mark W.
27. Analysis of Collagen Synthesis (pp. 349-358)
    Diegelmann, Robert F.
28. Method for Detection and Quantitation of Leukocytes During Wound Healing (pp. 359-368)
    Drugea, Iulia; Burns, Aime L.
29. Detection of Reactive Oxygen Intermediate Production by Macrophages (pp. 369-376)
    Albina, Jorge E.; Reichner, Jonathan S.
30. Measurement of Chemokines at the Protein Level in Tissue (pp. 377-388)
    Strieter, Robert M.; Burdick, Marie D.; Belperio, John A.; Keane, Michael P.
31. Methods of Measuring Oxygen in Wounds (pp. 389-416)
    Hopf, Harriet W.; Hunt, Thomas K.; Scheuenstuhl, Heinz; West, Judith M.; Humphrey, Lisa M.; Rollins, Mark D.
32. Isolation, Culture, and Characterization of Human Intestinal Smooth Muscle Cells (pp. 417-424)
    Willey, Martin Graham and Amy
33. Use of High-Throughput Microarray Membranes for cDNA Analysis of Cutaneous Wound Repair (pp. 425-432)
    Gibran, Nicole S.; Isik, F. Frank
34. Particle-Mediated Gene Therapy of Wounds (pp. 433-452)
    Davidson, Jeffrey M.; Eming, Sabine A.; Dasgupta, Jayasri

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