Library Science

Researchers from academia and biotechnology describe proven molecular methods for the construction, development, and use of virus vectors for gene transfer and gene therapy. Offering detailed step-by-step instructions to ensure successful results, these experts detail the use of herpes viruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, including lentiviruses, and other virus systems for vector development and gene transfer. Additional chapters demonstrate the use of virus vectors in the brain and central nervous system. Comprehensive and highly practical, Viral Vectors for Gene Therapy: Methods and Protocols provides not only researchers with the basic tools needed to design targeted gene delivery vectors, but also clinicians with an understanding of how to apply viral vectors to the treatment of genetic disorders.

Authors: C. A. Machida

Table of Contents

1. Use of the Herpes Simplex Viral Genome to Construct Gene Therapy Vectors (pp. 01-32)
   Burton, Edward A.; Huang, Shaohua; Goins, William F.; Glorioso, Joseph C.
2. Construction of Multiply Disabled Herpes Simplex Viral Vectors for Gene Delivery to the Nervous System (pp. 33-50)
   Lilley, Caroline E.; Coffin, Robert S.
3. Improved HSV-1 Amplicon Packaging System Using ICP27-Deleted, Oversized HSV-1 BAC DNA (pp. 51-60)
   Saeki, Yoshinaga; Breakefield, Xandra O.; Chiocca, E. Antonio
4. Herpes Simplex Amplicon Vectors (pp. 61-88)
   Link, Charles J.; Vahanian, Nicholas N.; Wang, Suming
5. Strategies to Adapt Adenoviral Vectors for Targeted Delivery (pp. 89-112)
   ORiordan, Catherine R.; Song, Anthonius; Lanciotti, Julia
6. Use of Recombinant Adenovirus for Gene Transfer into the Rat Brain: Evaluation of Gene Transfer Efficiency, Toxicity, and Inflammatory and Immune Reactions (pp. 113-134)
   Hurtado-Lorenzo, Andres; David, Anne; Thomas, Clare; Castro, Maria G.; Lowenstein, Pedro R.
7. Generation of Adenovirus Vectors Devoid of All Viral Genes by Recombination Between Inverted Repeats (pp. 135-152)
   Stecher, Hartmut; Carlson, Cheryl A.; Shayakhmetov, Dmitry M.; Lieber, Andre
8. Packaging Cell Lines for Generating Replication-Defective and Gutted Adenoviral Vectors (pp. 153-166)
   Chamberlain, Jeffrey S.; Barjot, Catherine; Scott, Jeannine
9. Improving the Transcriptional Regulation of Genes Delivered by Adenovirus Vectors (pp. 167-200)
   Rubinchik, Semyon; Woraratanadharm, Jan; Schepp, Jennifer; Dong, Jian-yun
10. Targeted Integration by Adeno-Associated Virus (pp. 201-220)
    Weitzman, Matthew D.; Young, Samuel M.; Cathomen, Toni; Samulski, Richard Jude
11. Development and Optimization of Adeno-Associated Virus Vector Transfer into the Central Nervous System (pp. 221-236)
    During, Matthew J.; Young, Deborah; Baer, Kristin; Lawlor, Patricia; Klugmann, Matthias
12. A Method for Helper Virus-Free Production of Adeno-Associated Virus Vectors (pp. 237-254)
    Collaco, Roy F.; Trempe, James P.
13. Novel Tools for Production and Purification of Recombinant Adeno-Associated Viral Vectors (pp. 255-268)
    Harris, Julian D.; Beattie, Stuart G.; Dickson, J. George
14. Recombinant Adeno-Associated Viral Vector Types 4 and 5: Preparation and Application for CNS Gene Transfer (pp. 269-286)
    Davidson, Beverly L.; Chiorini, John A.
15. Trans-Splicing Vectors Expand the Packaging Limits of Adeno-Associated Virus for Gene Therapy Applications (pp. 287-308)
    Duan, Dongsheng; Yue, Yongping; Yan, Ziying; Engelhardt, John F.
16. Generation of Retroviral Packaging and Producer Cell Lines for Large-Scale Vector Production with Improved Safety and Titer (pp. 309-330)
    Dubensky, Thomas W.; Sauter, Sybille L.
17. An Ecdysone-Inducible Expression System for Use with Retroviruses (pp. 331-342)
    Morse, Karen; Olsen, John
18. In Vivo Infection of Mice by Replication-Competent MLV-Based Retroviral Vectors (pp. 343-352)
    Bachrach, Estanislao; Duch, Mogens; Pelegrin, Mireia; Dreja, Hanna; Pedersen, Finn Skou; Piechaczyk, Marc
19. Development of Simian Retroviral Vectors for Gene Delivery (pp. 353-366)
    Li, Biao; Machida, Curtis A.
20. Self-Inactivating Lentiviral Vectors and a Sensitive Cre-loxP Reporter System (pp. 367-382)
    Chang, Lung-Ji; Zaiss, Anne-Kathrin
21. Lentiviral Vectors for Gene Transfer to the Central Nervous System: Applications in Lysosomal Storage Disease Animal Models (pp. 383-404)
    Watson, Deborah J.; Wolfe, John H.
22. A Highly Efficient Gene Delivery System Derived from Feline Immunodeficiency Virus (FIV) (pp. 405-432)
    Sauter, Sybille L.; Gasmi, Mehdi; Dubensky, Thomas W.
23. A Multigene Lentiviral Vector System Based on Differential Splicing (pp. 433-448)
    Zhu, Yonghong; Planelles, Vicente
24. Production of Trans-Lentiviral Vector with Predictable Safety (pp. 449-466)
    Kappes, John C.; Wu, Xiaoyun; Wakefield, John K.
25. Human Immunodeficiency Virus Type 1-Based Vectors for Gene Delivery to Human Hematopoietic Stem Cells (pp. 467-492)
    Ramezani, Ali; Hawley, Robert G.
26. Semliki Forest Virus Vectors for Gene Transfer (pp. 493-502)
    Wahlfors, Jarmo; Morgan, Richard A.
27. Semliki Forest Virus (SFV) Vectors in Neurobiology and Gene Therapy (pp. 503-524)
    Lundstrom, Kenneth; Ehrengruber, Markus U.
28. Semliki Forest Virus Vectors for Large-Scale Production of Recombinant Proteins (pp. 525-544)
    Lundstrom, Kenneth
29. Development of Foamy Virus Vectors (pp. 545-564)
    Vassilopoulos, George; Josephson, Neil C.; Trobridge, Grant
30. Poxviral/Retroviral Chimeric Vectors Allow Cytoplasmic Production of Transducing Defective Retroviral Particles (pp. 565-578)
    Holzer, Georg W.; Falkner, Falko G.

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