Library Science

Expert practitioners present a comprehensive approach to vaccine development, production, and assessment that can be adapted successfully to any vaccine. Their approach not only includes state-of-the-art techniques for developing live viral and bacterial vectors, expressing foreign vaccine antigens, and producing peptide and conjugate vaccines, but also offers advice and guidance on clinical trials and regulatory requirements. Additional techniques describe such powerful tools as the use of adjuvants, freeze drying vaccines, microencapsulation of vaccines, the full assessment of immunogenicity and potency of vaccines in animal models, and the creation of DNA vaccines, chimeric proteins, and recombinant toxoids.

Table of Contents

1. Overview of Vaccines (pp. 1-16)
   Ada, Gordon
2. Temperature-Sensitive Mutant Vaccines (pp. 17-32)
   Pringle, Craig R.
3. Live Viral Vectors: Construction of a Replication- Deficient Recombinant Adenovirus (pp. 33-46)
   Warnes, Alan; Fooks, Anthony R.
4. Development of Attenuated Salmonella Strains that Express Heterologous Antigens (pp. 47-62)
   Anderson, Richard J.; Londono, L. Patricia; Pickard, Derek J.; Dougan, Gordon
5. Chimeric Proteins (pp. 63-74)
   Janssen, Riny; Tommassen, Jan
6. Synthetic Peptides (pp. 75-90)
   Francis, Michael J.
7. Genetic Detoxification of Bacterial Toxins (pp. 91-110)
   Pizza, Mariagrazia; Fontana, Maria Rita; Scarlato, Vincenzo; Rappuoli, Rino
8. PolysaccharicbConjugate Vaccines (pp. 111-134)
   Peeters, Carla C. A. M.; Lagerman, Patrick R.; de Weers, Odo; Oomen, Lukas A.; Hoogerhout, Peter; Beurret, Michel; Poolman, Jan T.
9. The Use of Adjuvants in Experimental Vaccines: I. Aluminum Hydroxide Gels (pp. 135-140)
   Stewart-Tull, Duncan E. S.
10. The Use of Adjuvants in Experimental Vaccines: II. Water-in-Oil Emulsions: Freud?s Complete and lncomple te Adjuvants (pp. 141-146)
    Stewart-Tull, Duncan E. S.
11. The Use of Adjuvants in Experimental Vaccines: III. Liposomes (pp. 147-152)
    Stewart-Tull, Duncan E. S.
12. The Use of Adjuvants in Experimental Vaccines: IV. ISCOMS (pp. 153-156)
    Stewart-Tull, Duncan E. S.
13. Microencapsulation of Vaccines (pp. 157-166)
    Jones, David H.
14. Lyophilization of Vaccines (pp. 167-186)
    Adams, Gerald D. J.
15. Stimulation of Mucosal Immunity (pp. 187-196)
    Lewis, David J. M.; Hayward, Christopher M. M.
16. Induction and Detection of T-Cell Responses (pp. 197-222)
    Mills, Kingston H. G.
17. Immunological Characterization (pp. 223-230)
    Redhead, Keith
18. Severe Combined lmmunodeficient (SCID) Mice in Vaccine Assessment (pp. 231-250)
    McBride, Brian W.
19. Clinical Trials (pp. 251-268)
    Farrington, Paddy; Miller, Elizabeth
20. Assuring the Quality of Vaccines: Regulatory Requirements for Licensing and Batch Release (pp. 269-288)
    Griffiths, Elwyn
21. DNA Vaccines (pp. 289-300)
    Ulmer, Jeffrey B.; Montgomery, Donna L.; Donnelly, John J.; Liu, Margaret A.
22. Cancer Vaccines (pp. 301-312)
    Durrant, Lindy G.; Buckley, T. J. Declan

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