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The second volume of Tumor Suppressor Genes explores the cell biology and biochemical function of the tumor suppressor genes, as well as its physiological role in vivo. The authors detail the physical methods (NMR, microarray approaches, pot-translational structure analysis, analysis of regulation at the gene expression and protein signaling levels)used to understand the function of tumor suppressor genes. In vivo approaches discussed include studies in yeast, Drosophilia, mice, and human tumors. For both volumes: Leading physician scientists and academic researchers review all the known tumor suppressor genes, explain how they work, and describe how they were discovered and isolated. In many cases, the authors discuss specific genes that are frequently involved in hereditary or sporadic cancers. They also provide a detailed guide to using powerful molecular genetic, cytogenetic, proteomic, and cell biological strategies to discover and isolate novel tumor suppressor genes and their targets. A second volume of this two-volume set, Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medical Applications, shows how to explore the cell biology and biochemical function of such encoded proteins, to study its physiological role in vivo, and to use information on TSGs to develop diagnostic and therapeutic strategies for cancer. Ed. El-Deiry, Wafik S.

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Table of Contents

1. Utilizing NMR to Study the Structure of Growth-Inhibitory Proteins (pp. 3-16)
   Marassi, Francesca M.
2. Generation and Application of Phospho-specific Antibodies for p53 and pRB (pp. 17-26)
   Taya, Yoichi; Nakajima, Kiichiro; Yoshizawa-Kumagaye, Kumiko; Tamai, Katsuyuki
3. Stability and Ubiquitination of the Tumor Suppressor Protein p53 (pp. 27-38)
   Jardine, Lesley J.; Maki, Carl G.
4. Role of Tumor Suppressors in DNA Damage Response (pp. 39-50)
   Zhou, Bin-Bing S.; Mattern, Michael R.; Khanna, Kum Kum
5. In Situ Hybridization in Cancer and Normal Tissue (pp. 51-72)
   Kadkol, Shrihari; Juang, Jeremy; Wu, Tzyy-choou
6. Genetic Strategies in Saccharomyces cerevisiae to Study Human Tumor Suppressor Genes (pp. 73-86)
   Kobayashi, Takahiko; Wang, Ting; Qian, Hua; Brachmann, Rainer K.
7. Electrophoretic Mobility Shift Analysis of the DNA Binding of Tumor Suppressor Gene Products (pp. 87-100)
   Thornborrow, Edward C.; Maurer, Matthew; Manfredi, James J.
8. Analysis of Gene Promoter Regulation by Tumor Suppressor Genes (pp. 101-116)
   Somasundaram, Kumaravel; Das, Sanjeev; Lakhotia, Smita; Wajapeyee, Narendra
9. DNA Footprinting (pp. 117-128)
   Ricci, M. Stacey; El-Deiry, Wafik S.
10. Identification of DNA-Binding of Tumor Suppressor Genes by Chromatin Immunoprecipitation (pp. 129-134)
    MacLachlan, Timothy K.; El-Deiry, Wafik S.
11. Co-immunoprecipitation of Tumor Suppressor Protein-Interacting Proteins (pp. 135-140)
    Su, Li-Kuo
12. Microarray Approaches for Analysis of Tumor Suppressor Gene Function (pp. 141-154)
    Amundson, Sally A.; Fornace, Albert J.
13. Analysis of Tumor Suppressor Gene-Induced Senescence (pp. 155-172)
    Campisi, Judith
14. Yeast Two-Hybrid Screening as a Means of Deciphering Tumor Suppressor Pathways (pp. 173-186)
    McDonald, E. Robert; El-Deiry, Wafik S.
15. Somatic Cell Knockouts of Tumor Suppressor Genes (pp. 187-206)
    Hemmer, Ruth; Wei, Wenyi; Dutriaux, Annie; Sedivy, John M.
16. Colony Growth Suppression by Tumor Suppressor Genes (pp. 207-210)
    Wu, Gen Sheng
17. Flow Cytometric Analysis of Cell Cycle Control by Tumor Suppressor Genes (pp. 211-216)
    Dicker, David T.; El-Deiry, Wafik S.
18. Analysis of Cyclin-Dependent Kinase Activity (pp. 217-220)
    MacLachlan, Timothy K.; El-Deiry, Wafik S.
19. Tumor Suppressor Gene-Inducible Cell Lines (pp. 221-236)
    Dohn, Michael; Nozell, Susan; Willis, Amy; Chen, Xinbin
20. In Vitro Models of Early Neoplastic Transformation of Human Mammary Epithelial Cells (pp. 237-248)
    Band, Vimla
21. Tumor Suppression Through Angiogenesis Inhibition (pp. 249-270)
    Arsham, Andrew M.; Simon, M. Celeste
22. Flow Cytometric Analysis of Tumor Suppressor Gene-Induced Apoptosis (pp. 271-282)
    Dicker, David T.; El-Deiry, Wafik S.
23. Functional Analysis of Tumor Suppressor Genes in Mice (pp. 283-314)
    Jones, Stephen N.; Donehower, Lawrence A.
24. The Tissue Microenvironment as an Epigenetic Tumor Modifier (pp. 315-348)
    Unger, Meredith; Weaver, Valerie M.
25. Analyzing the Function of Tumor Suppressor Genes Using a Drosophila Model (pp. 349-382)
    Pagliarini, Raymond A.; Quinones, Ana T.; Xu, Tian
26. Assembling a Tumor Progression Model (pp. 383-402)
    Redston, Mark
27. Conformation-Sensitive Gel Electrophoresis for Detecting BRCA1 Mutations (pp. 403-412)
    Lakhotia, Smita; Somasundaram, Kumaravel
28. Conversion Technology and Cancer Predispositions (pp. 415-424)
    Papadopoulos, Nickolas
29. Discovering Novel Anticancer Drugs Practical Aspects and Recent Advances (pp. 425-464)
    Lewis, Cristina T.; O’Connor, Patrick M.
30. Targets in Apoptosis Signaling Promise of Selective Anticancer Therapy (pp. 465-484)
    Nimmanapalli, Ramadevi; Bhalla, Kapil
31. Tumor Deprivation of Oxygen and Tumor Suppressor Gene Function (pp. 485-504)
    Yun, Zhong; Giaccia, Amato J.
32. Hormonal and Differentiation Agents in Cancer Growth Suppression (pp. 505-522)
    Blagosklonny, Mikhail V.
33. Regulation of NF-?B by Oncoproteins and Tumor Suppressor Proteins (pp. 523-532)
    Madrid, Lee V.; Baldwin, Albert S.
34. Blocking Survivin to Kill Cancer Cells (pp. 533-542)
    Altieri, Dario C.
35. Targeting the Mitochondria to Enhance Tumor Suppression (pp. 543-554)
    Gottlieb, Eyal; Thompson, Craig B.
36. Novel Approaches to Screen for Anticancer Drugs Using Saccharomyces cerevisiae (pp. 555-576)
    Simon, Julian A.; Yen, Timothy J.
37. Tumor Suppressor Gene Therapy (pp. 577-598)
    Roth, Jack A.; Grammer, Susan F.
38. Therapeutic Strategies Using Inhibitors of Angiogenesis (pp. 599-634)
    O’Reilly, Michael S.
39. Isolation of p53 Inhibitors by Screening Chemical Libraries in Cell-Based Readout System (pp. 635-648)
    Gudkov, Andrei; Komarova, Elena

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