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Leading physician scientists and academic researchers review all the known tumor suppressor genes, explain how they work, and describe how they were discovered and isolated. In many cases, the authors discuss specific genes that are frequently involved in hereditary or sporadic cancers. They also provide a detailed guide to using powerful molecular genetic, cytogenetic, proteomic, and cell biological strategies to discover and isolate novel tumor suppressor genes and their targets. For both volumes: Leading physician scientists and academic researchers review all the known tumor suppressor genes, explain how they work, and describe how they were discovered and isolated. In many cases, the authors discuss specific genes that are frequently involved in hereditary or sporadic cancers. They also provide a detailed guide to using powerful molecular genetic, cytogenetic, proteomic, and cell biological strategies to discover and isolate novel tumor suppressor genes and their targets. A second volume of this two-volume set, Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medical Applications, shows how to explore the cell biology and biochemical function of such encoded proteins, to study its physiological role in vivo, and to use information on TSGs to develop diagnostic and therapeutic strategies for cancer.      Ed. El-Deiry, Wafik S.

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Table of Contents

1. Growth Control by the Retinoblastoma Gene Family (pp. 003-019)
   Paggi, Marco G.; Felsani, Armando; Giordano, Antonio
2. The APC Tumor Suppressor Pathway (pp. 021-040)
   Morin, Patrice J.; Weeraratna, Ashani T.
3. Hereditary Breast and Ovarian Cancer Genes (pp. 041-057)
   Scully, Ralph; Puget, Nadine
4. Hereditary Colon Cancer Genes (pp. 059-083)
   Grady, William M.; Markowitz, Sanford D.
5. Patched, Hedgehog, and Skin Cancer (pp. 085-095)
   Quinn, Anthony G.; Epstein, Jr., Ervin
6. Tumor Suppressor Genes in Lung Cancer (pp. 097-115)
   Virmani, Arvind K.; Gazdar, Adi F.
7. TP53, hChk2, and the Li-Fraumeni Syndrome (pp. 117-129)
   Varley, Jenny
8. Genetic Alterations in Esophageal Cancer (pp. 131-145)
   Okano, Jun-ichi; Snyder, Lorraine; Rustgi, Anil K.
9. PTEN and Cancer (pp. 147-166)
   Parsons, Ramon; Simpson, Laura
10. VHL and Kidney Cancer (pp. 167-183)
    Ohh, Michael; Kaelin, Jr., William G.
11. p16INK4A and Familial Melanoma (pp. 185-195)
    Satyamoorthy, Kapaettu; Herlyn, Meenhard
12. The INK4a/ARF Locus and Human Cancer (pp. 197-209)
    Enders, Greg H.
13. Progression Model of Prostate Cancer (pp. 211-222)
    Almeida, Teresa Acosta; Papadopoulos, Nickolas
14. Neurofibromatosis Type 1 (pp. 223-237)
    McLaughlin, Margaret E.; Jacks, Tyler
15. Wilms’ Tumor as a Model for Cancer Biology (pp. 239-248)
    Feinberg, Andrew P.; Williams, Bryan R. G.
16. Inadequate “Caretaker” Gene Function and Human Cancer Development (pp. 249-268)
    DeWeese, Theodore L.; Nelson, William G.
17. The Regulation of Tumor Suppressor Genes by Oncogenes (pp. 269-292)
    Dent, Paul; Qiao, Liang; Gilfor, Donna; Birrer, Michael; Grant, Steven; Fisher, Paul B.
18. Determination of Cancer Allelotype (pp. 295-307)
    Ascano, Jennifer J.; Powell, Steven M.
19. Epidemiological Approaches to the Identification of Cancer Predisposition Genes (pp. 309-325)
    Rebbeck, Timothy R.
20. Characterization of Translocations in Human Cancer (pp. 327-337)
    Fair, Keri; Le Beau, Michelle M.
21. Positional Approaches to Cancer Genetics (pp. 339-364)
    Robertson, Gavin P.; Sargent, Linda; Nelson, Mark A.
22. Hybrid Capture of Putative Tumor Suppressor Genes (pp. 365-373)
    Betz, Bryan L.; Weissman, Bernard E.
23. Approaches to Proteomic Analysis of Human Tumors (pp. 375-384)
    Ahram, Mamoun; Emmert-Buck, Michael R.
24. Representational Difference Analysis of Gene Expression (pp. 385-397)
    Bugni, James M.; Drinkwater, Norman R.
25. Antisense Libraries to Isolate Tumor Suppressor Genes (pp. 399-412)
    Kimchi, Adi
26. Genetic Suppressor Elements in the Characterization and Identification of Tumor Suppressor Genes (pp. 413-436)
    Roninson, Igor B.; Gudkov, Andrei V.
27. Cross-linking Subtractive Hybridization to Identify Tumor Suppressor Genes (pp. 437-451)
    Wu, Gen Sheng
28. Suppression Subtractive Hybridization for Identification and Functional Analysis of Tumor Suppressor Genes (pp. 453-462)
    Louro, Iuri D.; Bailey, Evans C.; Ruppert, J. Michael
29. SAGE as a Strategy to Isolate Cancer-Related Genes (pp. 463-479)
    Boon, Kathy; Riggins, Gregory J.
30. Differential Display Techniques to Identify Tumor Suppressor Gene Pathways (pp. 481-490)
    Biade, Siham; Murphy, Maureen E.
31. Detection of Mismatch Repair Gene Expression in Urologic Malignancies (pp. 491-499)
    Leach, Fredrick S.

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