Library Science

A comprehensive collection of readily reproducible techniques for TNF production, characterization, mutagenesis, and detection in biological specimens. Also included are several in vitro assays and animal models for studying the role of TNF in various TNF-related diseases and in cancer. The collection offers molecular and cellular biologists, pharmacologists, and toxicologists a diverse set of versatile, cutting-edge tools for illuminating the pathophysiological roles of TNF in disease and for identifying new drugs.

Authors: Corti, Angelo ; Ghezzi, Pietro

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Table of Contents

1. Tumor Necrosis Factor as a Pharmacological Target (pp. 001-008)
   Ghezzi, Pietro; Cerami, Anthony
2. Production and Characterization of Recombinant Human and Murine TNF (pp. 009-022)
   Curnis, Flavio; Corti, Angelo
3. Purification of TNF Binding Proteins (pp. 023-032)
   Engelmann, Hartmut; Aderka, Dani; Wallach, David
4. Production and Characterization of Receptor-Specific TNF Muteins (pp. 033-046)
   Ameloot, Paul; Brouckaert, Peter
5. TNFa Promoter Polymorphisms (pp. 047-058)
   Fargion, Silvia; Valenti, Luca; Dongiovanni, Paola; Fracanzani, Anna Ludovica
6. Detection of TNF and TNF Receptor mRNA in Cells and Tissues (pp. 059-072)
   Furlan, Roberto; Salani, Giuliana; Bergami, Alessandra; Martino, Gianvito
7. Immunohistochemical Localization of TNFa and Its Receptors in the Rodent Central Nervous System (pp. 073-080)
   Bigini, Paolo; Mennini, Tiziana
8. TNF Signaling: Key Protocols (pp. 081-100)
   Muzio, Marta; Saccani, Simona
9. More Than One Way to Die: Methods to Determine TNF-Induced Apoptosis and Necrosis (pp. 101-126)
   Vanden Berghe, Tom; Denecker, Geertrui; Brouckaert, Greet; Vadimovisch Krysko, Dmitri; D???Herde, Katharina; Vandenabeele, Peter
10. Assessment of TNFa-Induced Endothelial Damage Through the Loss of Its Barrier Function (pp. 127-136)
    Ferrero, Elisabetta
11. Genetic Engineering in the Mouse: Tuning TNF/TNFR Expression (pp. 137-170)
    Douni, Eleni; Alexiou, Maria; Kollias, George
12. TNFa in Experimental Diseases of the CNS (pp. 171-190)
    Furlan, Roberto; Villa, Pia; Senaldi, Giorgio; Martino, Gianvito
13. In Vivo Vascular Leakage Assay (pp. 191-198)
    Elena Ferrero, Maria
14. Animal Models of Endotoxic Shock (pp. 199-206)
    Villa, Pia; Ghezzi, Pietro
15. Collagen-Induced Arthritis as a Model for Rheumatoid Arthritis (pp. 207-216)
    Williams, Richard O.
16. Myocardial Infarction: Animal Models (pp. 217-226)
    Chimenti, Stefano; Carlo, Eleonora; Masson, Serge; Bai, Antonio; Latini, Roberto
17. Tumor Vascular Therapy With TNF: Critical Review on Animal Models (pp. 227-246)
    Hagen, Timo L. M. ten; Eggermont, Alexander M. M.
18. Strategies for Improving the Anti-Neoplastic Activity of TNF by Tumor Targeting (pp. 247-264)
    Corti, Angelo

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