Library Science

A much-needed collection of cutting-edge methods for the detection and discovery of new cancer markers, particularly molecular tumor markers. Each method is fully described by a hands-on expert who regularly uses it in the laboratory and has perfected it to a high degree of ready reproducibility. Special emphasis is given to statistical considerations in the analysis of tumor markers, recent discoveries in the field of serum and tissue marker proteins, cytogenetic markers, molecular markers, and markers for the early detection of cancer. The well-honed procedures detailed here will enable cancer researchers and clinical oncologists alike to realize the promise of these powerful new diagnostic strategies for the detection, therapy, and successful prevention of cancer.

Ed. Hanausek, Margaret ; Walaszek, Zbigniew Table of Contents

1. Integrating Multiple Clinical Tests to Increase Predictive Power (pp. 3-10)
   Burke, Harry B.
2. Statistical Considerations in the Analysis of Tumor Markers (pp. 11-36)
   Johnston, Dennis A.
3. Selection and Development of Biomarkers for Bladder Cancer (pp. 37-60)
   Hemstreet, George P.; Hurst, Robert E.; Bonner, Rebecca B.
4. Clinical Application of Tissue and Serum Markers in Breast Cancer (pp. 61-91)
   Schwartz, Gordon F.; Schwarting, Roland
5. Serum and Tissue Biomarkers in the Prognosis and Treatment of Breast Cancer (pp. 95-102)
   Hieken, Tina J.; Mehta, Rajeshwari R.
6. The Oncofetal Protein p65 in Breast Cancer Detection (pp. 103-114)
   Hanausek, Margaret; Walaszek, Zbigniew; Sherman, Ute; Klijanienko, Jerzy T.
7. Determination of Tumor Ferritin Concentration in Breast Cancer (pp. 115-126)
   Head, Jonathan F.; Elliott, Robert L.
8. lmmunodiagnosis of Childhood Malignancies (pp. 127-142)
   Parham, David M.; Holt, Hallie
9. lmmunohistochemical Evaluation of Biomarkers in Prostatic and Colorectal Neoplasia: Principles and Guidelines (pp. 143-160)
   Grizzle, William E.; Myers, Russell B.; Manne, Upender; Srivastava, Sudhir
10. Factors Affecting lmmunohistochemical Evaluation of Biomarker Expression in Neoplasia (pp. 161-180)
    Grizzle, William E.; Myers, Russell B.; Manne, Upender; Stockard, Cecil R.; Harkins, Lualhati E.; Srivastava, Sudhir
11. Instrumentation, Accuracy, and Quality Control Issues in Development of Quantitative Fluorescence-Image Analysis (QFIA) (pp. 181-205)
    Bonner, Rebecca B.; Hurst, Robert E.; Rao, Jian Yu; Hemstreet, George P.
12. Cytogenetics as a Diagnostic Aid for Childhood Hematologic Disorders: Conventional Cytogenetic Techniques, Fluorescence In Situ Hybridization, and Comparative Genomic Hybridization (pp. 209-228)
    Raimondi, Susana C.; Mathew, Susan; Pui, Ching-Hon
13. Preparation of Metaphase Chromosomes for Cytogenetic Analysis (pp. 229-238)
    Hahn, Kevin A.; Riggs, Penny K.
14. Chromosome Staining and Banding Techniques (pp. 239-244)
    Hahn, Kevin A.; Riggs, Penny K.
15. Fluorescence ln Situ Hybridization to Chromosomes (pp. 245-254)
    Riggs, Penny K.; Hahn, Kevin A.
16. Detection of Rearrangements in the bcl-2 Gene Using the Polymerase Chain Reaction (pp. 255-266)
    Craig, Ruth W.; Belloni, Dorothy R.; Kawasaki, Ernest S.; Levy, Norman B.
17. Applications of Tissue Microdissection in Molecular Pathology: Principles and Guidelines (pp. 269-298)
    Emmert-Buck, Michael R.; Lubensky, lrina A.; Chuaqui, Rodrigo F.; Debelenko, Larisa V.; Vocke, Cathy D.; Merino, Maria J.; Duray, Paul H.; Linehan, W. Marston; Liotta, Lance A.
18. EWS Gene Fusions as Diagnostic Markers in Sarcomas: Principles and Guidelines (pp. 299-318)
    Ladanyi, Marc
19. p53 Detection in Breast Cancer (pp. 319-330)
    Davis, Penelope L.; lglehart, J. Dirk
20. Use of the Polymerase Chain Reaction Technique to Detect the t(14;18) Translocation in Lymphoid Tissue (pp. 331-340)
    Stetler-Stevenson, Maryalice; Lim, Megan S.
21. Detection of ras Gene Mutations Using Oligonucleotide Ligation Technology (pp. 341-356)
    Eggerding, Faye A.
22. Detection of Prostate-Cancer Cells in Blood and Bone Marrow by RT-PCR (pp. 357-372)
    Vessella, Robert L.; Corey, Eva
23. Quantitative, Competitive RT-PCR Analysis of Biomarkers in the Study of Neoplasia (pp. 373-390)
    Hackett, Richard D.; Rogers, Miriam D.; Srivastava, Sudhir
24. Differential Display to Define Molecular Markers and Genes That Mediate Malignancy (pp. 391-414)
    Pavlik, Edward J.; Nelson, Katherine; Srinivasan, Suseela; Johnson, Thomas L.; DePriest, Paul D.
25. Transforming Growth Factor Beta: A Plasma Tumor Marker (pp. 417-430)
    Kong, Feng-Ming; Anscher, Mitchell S.; Jirtle, Randy L.
26. Anti-HMdU Autoantibodies in Human Sera as a Biomarker of Cancer Risk (pp. 431-446)
    Frenkel, Krystyna; Karkoszka, Jerzy
27. A Scientific Basis for Cancer Prevention: Defining the Role of Individual Cytosolic GST lsozyme (pp. 447-464)
    K., Sanjay; Awasthi, Sanjay
28. Aberrant Crypt Foci System to Study Cancer Preventive Agents in the Colon: Principles and Guidelines (pp. 465-474)
    Bird, Ranjana P.
29. Strain-Dependent Differences in the Expression of the Oncofetal Protein p65 in Mice Susceptible and Resistant to Chemical Carcinogenesis (pp. 475-486)
    Szemraj, Janusz; Hanausek, Margaret; Walaszek, Zbigniew; Adams, Alan K.
30. D-Glucaric Acid as a ProspectiveTumor Marker (pp. 487-496)
    Walaszek, Zbigniew; Hanausek, Maragaret; Szemraj, Janusz; Adams, Alan K

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