Library Science

The first comprehensive review of both the theory and practice of suicide gene therapy. The authors cover all the major aspects of suicide gene therapy, including the design and use of vectors in gene transduction, various enzyme and prodrug systems, the mechanistic analysis of the bystander effect, the design and synthesis of prodrugs, immunological implications, and its clinical impact. They also describe all the cutting-edge methods needed to explore, study, and advance understanding of the basic biology underlying gene therapy. Each fully tested method includes step-by-step instructions, a discussion of the principle behind the technique, equipment and reagent lists, tips on troubleshooting and avoiding pitfalls, and notes on the interpretation and use of results.

Authors: Springer, Caroline J.

Full text:

Table of Contents

1. Introduction to the Background, Principles, and State of the Art in Suicide Gene Therapy (pp. 1-28)
   Niculescu-Duvaz, Ion; Springer, Caroline J.
2. Introduction to Vectors for Suicide Gene Therapy (pp. 29-46)
   Springer, Caroline J.
3. Construction of VNP20009: A Novel, Genetically Stable Antibiotic-Sensitive Strain of Tumor-Targeting Salmonella for Parenteral Administration in Humans (pp. 47-60)
   Low, Kenneth Brooks; Ittensohn, Martina; Luo, Xiang; Zheng, Li-Mou; King, Ivan; Pawelek, John M.; Bermudes, David
4. Nonreplicating DNA Viral Vectors for Suicide Gene Therapy: The Adenoviral Vectors (pp. 61-70)
   Yamamoto, Masato; Curiel, David T.
5. Replication-Selective Oncolytic Adenoviruses (pp. 71-90)
   Hallden, Gunnel; Thorne, Stephen H.; Yang, Jingping; Kirn, David H.
6. Retroviral Vectors for Suicide Gene Therapy (pp. 91-106)
   Porter, Colin
7. Nonviral Liposomes (pp. 107-138)
   Miller, Andrew D.
8. Peptide- and Polymer-Based Gene Delivery Vehicles (pp. 139-160)
   Brokx, Richard; Gariepy, Jean
9. Design of Prodrugs for Suicide Gene Therapy (pp. 161-202)
   Niculescu-Duvaz, Dan; Niculescu-Duvaz, Ion; Springer, Caroline J.
10. Cytochrome P450-Based Gene Therapies for Cancer (pp. 203-222)
    Chiocca, E. Antonio; Waxman, David J.
11. Tumor Sensitization to Purine Analogs by E. coli PNP (pp. 223-246)
    Curlee, Kimberly V.; Parker, William B.; Sorscher, Eric J.
12. Enzyme-Prodrug Systems: Carboxylesterase/CPT-11 (pp. 247-262)
    Danks, Mary K.; Potter, Philip M.
13. Enzyme-Prodrug Systems: Thymidine Phosphorylase/5???-Deoxy-5-Fluorouridine (pp. 263-278)
    Evrard, Alexandre; Ciccolini, Joseph; Cuq, Pierre; Cano, Jean-Paul
14. Methods to Improve Efficacy in Suicide Gene Therapy Approaches: Targeting Prodrug-Activating Enzymes Carboxypeptidase G2 and Nitroreductase to Different Subcellular Compartments (pp. 279-302)
    Schepelmann, Silke; Spooner, Robert; Friedlos, Frank; Marais, Richard
15. Extracellular ?÷-Glucuronidase for Gene-Directed Enzyme-Prodrug Therapy (pp. 303-330)
    Brusselbach, Sabine
16. Enhancement of Suicide Gene Prodrug Activation by Random Mutagenesis (pp. 331-344)
    Kurtz, Jean-Emmanuel; Black, Margaret E.
17. Combination Suicide Gene Therapy (pp. 345-352)
    Uckert, Wolfgang; Salmons, Brian; Beltinger, Christian; Gunzburg, Walter H.; Kammertons, Thomas
18. Immune Response to Suicide Gene Therapy (pp. 353-370)
    Kuriyama, Shigeki; Tsujinoue, Hirohisa; Yoshiji, Hitoshi
19. Targeting Cancer With Gene Therapy Using Hypoxia as a Stimulus (pp. 371-388)
    Dachs, Gabi U.; Greco, Olga; Tozer, Gillian M.
20. Radiation-Activated Antitumor Vectors (pp. 389-402)
    Scott, Simon D.; Marples, Brian
21. In Vitro and In Vivo Models for Evaluation of GDEPT: Quantifying Bystander Killing in Cell Cultures and Tumors (pp. 403-432)
    Wilson, William R.; Pullen, Susan M.; Hogg, Alison; Hobbs, Stephen M.; Pruijn, Frederik B.; Hicks, Kevin O.
22. Suicide Gene Therapy in Liver Tumors (pp. 433-450)
    Jiao, Long R.; Havlik, Roman; Nicholls, Joanna; Jensen, Steen Lindkaer; Habib, Nagy A.
23. Clinical Trials With GDEPT: Cytosine Deaminase and 5-Fluorocytosine (pp. 451-458)
    Brown, Nicola L.; Lemoine, Nicholas R.
24. The Nitroreductase/CB1954 Enzyme-Prodrug System (pp. 459-478)
    Green, Nicola K.; Kerr, David J.; Mautner, Vivien; Harris, Peter A.; Searle, Peter F.
25. Side Effects of Suicide Gene Therapy (pp. 479-490)
    van der Eb, Marjolijn M.; de Leeuw, Bertie; van der Eb, Alex J.; Hoeben, Rob C.
26. Antibody-Directed Enzyme-Prodrug Therapy (pp. 491-514)
    Pedley, R. Barbara; Sharma, Surinder K.; Hawkins, Robert E.; Chester, Kerry A.
27. Bioreductive Prodrugs for Cancer Therapy (pp. 515-542)
    Seddon, Beatrice; Kelland, Lloyd R.; Workman, Paul

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