Library Science

Leading experts distill their extensive experience into user-friendly methods for the study of fluid???electrolyte homeostasis and kidney function in health and disease. Described in step-by-step detail, the techniques move from the molecular level to the whole organism, from simple models to integrative physiology. Here the researcher will find established disease models, methods for optimizing renal disease research, as well as much help in choosing imaging techniques for studies of the kidney’s structure and function in health, disease, and during embryonic development. Subjects covered include molecular diagnostics, strategies for studying the molecular mechanisms of kidney disease, technical means to assess the functional correlates of disease, and the planning of clinical trials.

Authors: Goligorsky, Michael S.

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Table of Contents

1. Standards of Animal Care in Biological Experiments (pp. 3-12)
   Levee, Ellen M.
2. Models of Polycystic Kidney Disease (pp. 13-28)
   Upadhya, Poornima
3. Rat Models of the Metabolic Syndrome (pp. 29-46)
   Tofovic, Stevan P.; Jackson, Edwin K.
4. Models of Glomerulonephritis (pp. 47-66)
   Durvasula, Raghu V.; Shankland, Stuart J.
5. Functional Studies of the Kidney with Magnetic Resonance Imaging (pp. 69-78)
   Marcos, Hani B.; Zhang, Yantian; Choyke, Peter L.
6. Use of Radionuclides to Study Renal Function (pp. 79-118)
   Liu, Yiyan; Blaufox, M. Donald
7. Intravital Videomicroscopy (pp. 119-128)
   Yamamoto, Tokunori; Kajiya, Fumihiko
8. Confocal and Two-Photon Microscopy (pp. 129-138)
   Peti-Peterdi, Janos; Bell, P. Darwin
9. Atomic Force Microscopy in Renal Physiology (pp. 139-154)
   Henderson, Robert M.
10. Freeze-Fracture Analysis of Renal-Epithelial Tight Junctions (pp. 155-166)
    Sasaki, Hiroyuki
11. Organ Culture of Intact Metanephric Kidneys (pp. 169-178)
    Welham, Simon J. M.; Woolf, Adrian S.
12. The Ureteric Bud: Tissue-Culture Approaches to Branching Morphogenesis and Inductive Signaling (pp. 179-192)
    Perantoni, Alan O.
13. Studies of Cell Lineage in the Developing Kidney (pp. 193-204)
    Lopez, Maria Luisa S. Sequeira; Gomez, R. Ariel
14. Transient Transfection Assays for Analysis of Signal Transduction in Renal Cells (pp. 205-218)
    Maser, Robin L.; Magenheimer, Brenda S.; Zien, Christopher A.; Calvet, James P.
15. The Study of Gene Polymorphisms: How Complex Is Complex Genetic Disease? (pp. 221-236)
    Bahring, Sylvia; Aydin, Atakan; Luft, Friedrich C.
16. Laser-Capture Microdissection (pp. 237-256)
    Barisoni, Laura; Star, Robert A.
17. Serial Analysis of Gene Expression (pp. 257-274)
    El-Meanawy, M. Ashraf; Barathan, Shrinath; Hayden, Patrick S.; Iyengar, Sudha K.; Schelling, Jeffrey R.; Sedor, John R.
18. RNA Labeling and Hybridization of DNA Microarrays (pp. 275-284)
    Bottinger, Erwin P.; Novetsky, Akiva; Zavadil, Jiri
19. Gene-Expression Analysis of Microdissected Renal Biopsies (pp. 285-294)
    Cohen, Clemens D.; Kretzler, Matthias
20. The Use of SELDI ProteinChip?? Array Technology in Renal Disease Research (pp. 295-312)
    Fung, Eric; Diamond, Deb; Simonsesn, Anja Hviid; Weinberger, Scot R.
21. Clearance Studies in Genetically Altered Mice (pp. 315-328)
    Noonan, William T.; Lorenz, John N.
22. Long-Term Blood-Pressure Monitoring in Unrestrained Animals (pp. 329-340)
    Griffin, Karen A.; Abu-Amarah, Isam; Bidani, Anil K.
23. In Vitro Studies on Renin Release (pp. 341-350)
    Jensen, Boye L.; Frus, Ulla G.; Skott, Ole
24. Mitochondrial Function (pp. 351-372)
    Weinberg, Joel M.; Saikumar, Pothana
25. Detection of Cysteine S-Nitrosylation and Tyrosine 3-Nitration in Kidney Proteins (pp. 373-384)
    Crabtree, Mark; Hao, Gang; Gross, Steven S.
26. Products of Arachidonic Acid Metabolism (pp. 385-398)
    Carroll, Mairead A.; McGiff, John C.; Ferreri, Nicholas R.
27. Methods for Measurements of Heme Oxygenase (HO) Isoforms-Mediated Synthesis of Carbon Monoxide and HO-1 and HO-2 Proteins (pp. 399-412)
    Abraham, Nader G.; Jiang, Houli; Balazy, Michael; Goodman, Alvin I.
28. The Juxtamedullary Nephron Preparation (pp. 413-428)
    Casellas, Daniel; Moore, Leon C.
29. Tubuloglomerular Feedback (pp. 429-442)
    Vallon, Volker; Schnermann, Jurgen
30. Microdissected Perfused Vessels (pp. 443-456)
    Pallone, Thomas L.
31. Renal Microperfusion Techniques (pp. 457-474)
    Wingo, Charles S.; Weiner, I. David; Xia, Shen-Ling
32. How to Design a Clinical Trial (pp. 475-490)
    Curtis, Bryan M.; Barrett, Brendan J.; Parfrey, Patrick S.
33. Conclusion: Mapping the Disease (pp. 491-494)
    Goligorsky, Michael S.

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