Quinones and Quinone Enzymes, Part B
posted in Enzymology |Developments in genomics and proteomics rapidly generated focus on new -omics, particularly metabolomics and phenomics. Quinones, hydroquinones, semiquinones and their metabolites are naturally occurring compounds that serve as wonderful examples for this new paradigm of interdigitating ,-omics. In addition to a role as substrates and products in metabolism, quinone compounds are intermediates in many pathways of gene regulation, enzyme protein induction, feedback control, and waste product elimination. Quinones play a pivotal role in energy metabolism (Peter Mitchell’s proton-motive, Q cycle’), many other key processes, and even in chemotherapy where redox cycling drugs are utilized.
The present volume of Methods in Enzymology on quinones and quinone enzymes serves to bring together current methods and concepts on this topic. It focuses on the role in the so-called Phase II of drug metabolism (xenobiotics), but include aspects on Phase I (CYP, cytochromes P-450) and Phase III (transport systems) as well. This volume of Methods in Enzymology, Part B addresses mitochondrial ubiquinone and reductases, anticancer quinones, and the role of quinone reductases in chemoprevention and nutrition, as well as the role of quinones in age-related diseases, whereas (Part A) focused on quinones and quinone enzymes in terms of coenzyme Q (detection and quinone reductases), plasma membrane quinone reductases, and the role of quinones in cellular signaling and modulation of gene expression. Phase II Enzymes, Part C, will be focusing on glutathione, glutathione S-transferases, and other conjugation enzymes.
The enzyme, NAD(P)H:quinone oxidoreductase, is the subject of a major section in this volume. This enzyme, discovered in 1958 in Stockholm by Lars Ernster, and named DT-Diaphorase by him, has multiple roles, some of which were only recently discovered.
Human polymorphisms exist in these enzymes that relate to variations in cancer risk, and enzymes targeted by quinones are being investigated. Modern methods in assaying quinone reactions and, indeed, various quinones themselves, are also included in this volume.
Following its discovery in 1957, ubiquinone (coenzyme Q10) as a major naturally occurring quinone became a highlight of scientific interest and an established role in mitochondrial electron transport by Frederick Crane. Fundamental contributions were made by Karl Folkers on its supplemental use for health benefits in disease prevention and by Andre? s O.M. Stoppani, a pioneer of Argentinian biochemistry, in utilizing quinones for the treatment of Chagas disease.
Ed. Helmut Sies and Lester Packer
quinones-and-quinone-enzymes-part-b.pdf
Table of Contents
- Editors-In-Chief (Page ii)
- Preface (pp.xv-xvi)
- Contributors to Volume 382 (pp.xi-xiv )
- Methods In Enzymology (pp.xvii-xxxviii )
- Mitochondrial Quinone Reductases: Complex I (pp3-20)
Giorgio Lenaz , Romana Fato , Alessandra Baracca and Maria Luisa Genova - Q-Cycle Bypass Reactions at the Qo Site of the Cytochrome bc1 (and Related) Complexes (pp21-45)
David M. Kramer , Arthur G. Roberts , Florian Muller , Jonathan Cape and Michael K. Bowman - Targeting Coenzyme Q Derivatives to Mitochondria (pp45-67)
Robin A. J. Smith , Geoffrey F. Kelso , Andrew M. James and Michael P. Murphy - The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia (pp67-81)
Constanza L. Lisdero , Maria Cecilia Carreras , Alain Meulemans , Mariana Melani , Michel Aubier , Jorge Boczkowski and Juan Jose Poderoso - Mitochondrial Respiratory Chain Dysfunction Caused by Coenzyme Q Deficiency (pp81-88)
Pierre Rustin , Arnold Munnich and Agnes Rotig - Coenzyme Q Cytoprotective Mechanisms (pp89-104)
Chan Tom S. , Wilson John X. and O’Brien Peter J. - Dietary Coenzyme Q10 and Mitochondrial Status (pp105-112)
Ching Kuang Chow - NAD(P)H:Quinone Oxidoreductase 1 (NQO1, DT-Diaphorase), Functions and Pharmacogenetics (pp115-144)
David Ross and David Siegel - Structure and Mechanism of NAD[P]H:Quinone Acceptor Oxidoreductases (NQO) (pp144-174)
Mario A. Bianchet , Margarita Faig and L. Mario Amzel - Diaziridinylbenzoquinones (pp174-193)
Angela Maria Di Francesco , Timothy H. Ward and John Butler - Quinone Reductase–Mediated Nitro-Reduction: Clinical Applications (pp194-221)
Richard J. Knox and Shiuan Chen - Bioactivation and Resistance to Mitomycin C (pp221-233)
Helen A. Seow , Philip G. Penketh , Raymond P. Baumann and Alan C. Sartorelli - NAD(P)H:Quinone Oxidoreductase 1 Expression, Hydrogen Peroxide Levels, and Growth Phase in HeLa Cells (pp234-243)
Rosario I. Bello , Consuelo Gomez-Diaz , Placido Navas and Jose M. Villalba - The “Prochaska” Microtiter Plate Bioassay for Inducers of NQO1 (pp243-258)
Jed W. Fahey , Albena T. Dinkova-Kostova , Katherine K. Stephenson and Paul Talalay - Structure-Activity Relationships in Two-Electron Reduction of Quinones (pp258-277)
Narimantas nas , ilvinas Anuseviius , Henrikas Nivinskas , Lina Miseviien and Jonas arlauskas - p53-Dependent Apoptosis and NAD(P)H:Quinone Oxidoreductase 1 (pp278-293)
Gad Asher , Joseph Lotem , Leo Sachs and Yosef Shaul - The Role of Endogenous Catechol Quinones in the Initiation of Cancer and Neurodegenerative Diseases (pp293-319)
Ercole Cavalieri , Eleanor Rogan and Dhrubajyoti Chakravarti - Induction of NQO1 in Cancer Cells (pp320-351)
Asher Begleiter and Jeanne Fourie - Role of Nicotinamide Quinone Oxidoreductase 1 (NQO1) in Protection against Toxicity of Electrophiles and Reactive Oxygen Intermediates (pp355-364)
Paul Talalay and Albena T. Dinkova-Kostova - Activation and Detoxification of Naphthoquinones by NAD(P)H: Quinone Oxidoreductase (pp364-380)
Rex Munday - Induction of Quinone Reductase as a Primary Screen for Natural Product Anticarcinogens (pp380-414)
Young-Hwa Kang and John M. Pezzuto - Chemoprevention by 1,2-Dithiole-3-Thiones Through Induction of NQO1 and Other Phase 2 Enzymes (pp414-423 )
Mi-Kyoung Kwak , Minerva Ramos-Gomez , Nobunao Wakabayashi and Thomas W. Kensler - Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1) (pp423-448)
Albena T. Dinkova-Kostova , Jed W. Fahey and Paul Talalay - Induction of Phase II Enzymes by Aliphatic Sulfides Derived from Garlic and Onions: An Overview (pp449-456)
Rex Munday and Christine M. Munday - Upregulation of Quinone Reductase by Glucosinolate Hydrolysis Products From Dietary Broccoli (pp457-469)
Elizabeth H. Jeffery and Kristin E. Stewart - Therapeutic Effects of Coenzyme Q10 in Neurodegenerative Diseases (pp473-487)
M. Flint Beal - Neuroprotective Actions of Coenzyme Q10 in Parkinson’s Disease (pp488-509)
S. Sharma , M. Kheradpezhou , S. Shavali , H. El Refaey , J. Eken , C. Hagen and M. Ebadi
- Author Index (pp511-559 )
- Subject Index (pp561-572)