Library Science

Leading researchers and clinicians describe their state-of-the-art findings and hypotheses arising from a variety of different approaches to this group of diseases. Their approaches include clinical presentations, epidemiology, transgenic methods, and diagnostic tests via transmission electron microscopy and immunoblotting. The diseases treated range from human to animal spongiform encephalopathies and include Creutzfeldt-Jakob disease, mad cow disease, and scrapie.

Ed. Baker, Harry F. ; Ridley, Rosalind M.

Table of Contents

1. The Paradox of Prion Disease (pp. 1-14) Ridley, Rosalind M.; Baker, Harry F.
2. Human Spongiform Encephalopathy: Clinical Presentation and Diagnostic Tests (pp. 15-34) de Silva, Rajith
3. Neuropathological Diagnosis of Human Prion Disease: Morphological Studies (pp. 35-58) lronside, James W.
4. Neuropathological Diagnosis of Human Prion Disease: PrP Immunocytochemical Techniques (pp. 59-84) Bell, Jeanne E.
5. The Diagnosis of Bovine Spongiform Encephalopathy and Scrapie by the Detection of Fibrils and the Abnormal Protein lsoform (pp. 85-104)
   Stack, Michael J.; Keyes, Paula; Scott, Anthony C.
6. Exposure to, and Inactivation of, the Unconventional Agents that Cause Transmissible Degenerative Encephalopathies (pp. 105-118) Taylor, David M.
7. Surveillance of Prion Diseases in Humans (pp. 119-138) Will, Robert G.
8. Environmental Causes of Human Spongiform Encephalopathy (pp. 139-154)
   Brown, Paul
9. Bovine Spongiform Encephalopathy: Methods of Analyzing the Epidemic in the United Kingdom (pp. 155-174) Wilesmith, John W.
10. Handling the BSE Epidemic in Great Britain (pp. 175-198) Tyrrell, David A. J.; Taylor, Kevin C.
11. Special Problems of Genetic Counseling in Adult-Onset Diseases: Huntington?s Disease as a Model (pp. 199-210) Gray, Jonathon FL; Soldan, Jo R.; Harper, Peter S.
12. Genotyping and Susceptibility of Sheep to Scrapie (pp. 211-222) Hunter, Nora
13. Strain Typing Studies of Scrapie and BSE (pp. 223-236) Bruce, Moira E.
14. PrP-Deficient Mice in the Study of Transmissible Spongiform Encephalopathies (pp. 237-250) Manson, Jean C.
15. Transgenic Approaches to Prion ?Species-Barrier? Effects (pp. 251-264) Westaway, David
16. Methods for Studying Prion Protein (pp. 265-284) Tagliavini, Amyloid Fabrizio; Prelli, Frances; Giaccone, Giorgio; Forloni, Gianluigi; Salmona, Mario; Piccardo, Pedro; Ghetti, Bernardino; Frangione, Blas; Bugiani, Orso
17. Methods for Studying Prion Protein (PrP) Metabolism and the Formation of Protease-Resistant PrP in Cell Culture and Cell-Free Systems (pp. 285-300)
    Caughey, Byron; Kocisko, David A.; Priola, Suzette A.; Raymond, Gregory J.; Race, Richard E.; Bessen, Richard A.; Lansbury, Peter T.; Chesebro, Bruce
18. lmmunohistochemistry of Resinated Tissues for Light and Electron Microscopy (pp. 301-312)
    Jeffrey, Martin; Goodsir, Caroline M.

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