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Internationally recognized biomedical investigators describe in detail the major techniques employed in molecular and cellular studies of Parkinson’s disease and basal ganglia function. Widely varied methods are covered, including genetic analyses, molecular pathogenetic investigations of dopaminergic neuronal degeneration, biochemical studies of nigro-striatal neural circuitry, and molecular therapies, such as gene therapy and neural stem cells. Comprehensive and timely, Parkinson’s Disease: Methods and Protocols offers scientists and clinicians interested in Parkinson’s and related neurodegenerative disorders the major cutting-edge methods-in a readily reproducible format-needed to effectively exploit the potential of cell and molecular biology for elucidating disease mechanisms and for speeding the emergence of novel and more effective therapeutics.

Authors: Mouradian, M. Maral

Table of Contents

1. Point Mutations in the a -Synuclein Gene (pp. 3-11)
   Parsian, Abbas; Perlmutter, Joel S.
2. Autosomal Recessive Juvenile Parkinsonism (AR-JP): Genetic Diagnosis (pp. 13-28)
   Matsumine, Hiroto; Hattori, Nobutaka; Mizuno, Yoshikuni
3. Parkinson???s Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as a-Synucleinopathies (pp. 33-59)
   Goedert, Michel; Jakes, Ross; Crowther, R. Anthony; Spillantini, Maria Grazia
4. a-Synuclein/Amyloid Interactions (pp. 61-65)
   Jensen, Poul Henning
5. Functional Defect Conferred by the Parkinson???s Disease-Causing a-Synuclein (Ala30Pro) Mutation (pp. 67-72)
   Jensen, Poul Henning
6. Molecular Biology of Dopamine-Induced Apoptosis: Possible Implications for Parkinson???s Disease (pp. 73-87)
   Ziv, Ilan; Shirvan, Anat; Offen, Daniel; Barzilai, Ari; Melamed, Eldad
7. Animal Models of Induced Apoptotic Death in the Substantia Nigra (pp. 89-99)
   Oo, Tinmarla F.; Burke, Robert E.
8. Apoptotic Morphology in Phenotypically Defined Dopaminergic Neurons of the Substantia Nigra (pp. 101-112)
   Oo, Tinmarla F.; Burke, Robert E.
9. The Role of Nitric Oxide in Parkinson???s Disease (pp. 113-136)
   Przedborski, Serge; Dawson, Ted M.
10. Oxidative Stress Indices in Parkinson???s Disease: Biochemical Determination (pp. 137-153)
    Youdim, Moussa B. H.; Drigues, Noam; Mandel, Silvia
11. Quantification of Tyrosine Hydroxylase mRNA (pp. 157-166)
    Ichinose, Hiroshi; Ohye, Tamae; Suzuki, Takahiro; Inagaki, Hidehito; Nagatsu, Toshiharu
12. Immunochemical Analysis of Dopamine Transporters in Parkinson???s Disease (pp. 167-177)
    Miller, Gary W.; Levey, Allan I.
13. Dopamine Transporter and Vesicular Monoamine Transporter Knockout Mice: Implications for Parkinson???s Disease (pp. 179-190)
    Miller, Gary W.; Wang, Yan-Min; Gainetdinov, Raul R.; Caron, Marc G.
14. Transcription Mechanisms for Dopamine Receptor Genes (pp. 191-215)
    Lee, Sang-Hyeon; Mouradian, M. Maral
15. Detection of DNA/Protein Interactions in Dopamine Receptor Genes (pp. 217-227)
    Lee, Sang-Hyeon; Mouradian, M. Maral
16. In Situ Hybridization on Brain Tissue (pp. 229-246)
    Lammers, Claas-Hinrich; Hara, Yoshinobu; Mouradian, M. Maral
17. Regulation of Striatal N-Methyl-D-Aspartate Receptor (NMDAR) Function by Phosphorylation of its Subunits in Parkinsonian Rats (pp. 247-253)
    Oh, Justin D.
18. Chronic Intracerebral Delivery of Trophic Factors via a Programmable Pump as a Treatment for Parkinsonism (pp. 257-267)
    Grondin, Richard; Zhang, Zhiming; Elsberry, Dennis D.; Gerhardt, Greg A.; Gash, Don M.
19. Grafting Genetically Engineered Cells into the Striatum of Nonhuman Primates (pp. 269-278)
    Bankiewicz, Krys S.; Pivirotto, Phillip; Sanchez-Pernaute, Rosario; Major, Eugene O.
20. Encapsulated Cell Implants as a Novel Treatment for Parkinson???s Disease (pp. 279-288)
    Tseng, Jack L.; Aebischer, Patrick
21. Neural Stem Cell Technology as a Novel Treatment for Parkinson???s Disease (pp. 289-307)
    Armstrong, Richard J. E.; Rosser, Anne E.; Dunnett, Stephen B.; Barker, Roger A.
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