Library Science

In Melanoma Techniques and Protocols: Molecular Diagnosis, Treatment, and Monitoring, a broadly diverse group of researchers and clinicians offer not only reviews of the most important recent advances in melanoma oncology, tumor immunology, and pathology, but also state-of-the-art molecular techniques for probing its basic biology. These readily reproducible methods can be used to develop new diagnostic approaches, therapeutics, and status monitoring of patients suffering both early- and late-stage melanoma. With emphasis on the experimental details critical to experimental success, each method is described in step-by-step fahion by hands-on masters, often those who have developed hem in their own laboratories. Comprehensive and highly instructive, Melanoma Techniques and Protocols: Molecular Diagnosis, Treatment, and Monitoring offers both clinicians and basic scientists concerned with malignant melanoma both new clinical perspectives and the wide ranging experimental protocols essential for achieving more rapid breakthroughs in this near-epidemic disease.

Authors: B.J. Nickoloff

Table of Contents

1. The Many Molecular Mysteries of Melanoma (pp. 3-14)
   Nickoloff, Brian J.
2. Isolation of Tumor Suppressor Genes in Melanoma by cDNA Microarray (pp. 15-29)
   Su, Yan A.; Trent, Jeffrey M.
3. Molecular Characterization of Melanoma-Derived Antigens (pp. 31-70)
   Visser, Marten; Velders, Markwin P.; Rudolf, Michael P.; Kast, W. Martin
4. Experimental Induction of Human Atypical Melanocytic Lesions and Melanoma in Ultraviolet-Irradiated Human Skin Grafted to Immunodeficient Mice (pp. 71-84)
   Berking, Carola; Herlyn, Meenhard
5. Dissection of Immunosuppressive Effects of Ultraviolet Radiation (pp. 85-97)
   Ullrich, Stephen E.; Schmitt, David A.
6. Antisense Oligonucleotides as Research Tools (pp. 99-106)
   Taylor, Jennifer K.; Cooper, Scott R.; Dean, Nicholas M.
7. Genetic Testing in Familial Melanoma: Epidemiologic/Genetic Assessment of Risks and Role ofCDKN2A Analysis (pp. 109-122)
   Hogg, David; Liu, Ling; Lassam, Norman
8. Role of Molecular Biology in Diagnostic Pathology of Melanoma (pp. 123-163)
   Slominski, Andrzej; Carlson, Andrew; Wortsman, Jacobo; Mihm, Martin C.
9. Identification of Altered Gene Expression Associated with Pigmentary Lesions by Differential Display Analysis (pp. 165-179)
   Le Poole, I. Caroline; Brown, Thomas L.
10. Fluorescence In Situ Hybridization as a Tool in Molecular Diagnostics of Melanoma (pp. 181-191)
    Coignet, Lionel J.
11. Antigen-Pulsed Dendritic Cell Approach to Melanoma (pp. 195-202)
    Nestle, Frank O.; Tun-Kyi, Adrian; Gilliet, Michel F.
12. Gene Therapy in Melanoma (pp. 203-222)
    Parmiani, Giorgio; Arienti, Flavio; Melani, Cecilia; Belli, Filiberto; Gallino, Gianfrancesco; Mazzocchi, Arabella
13. Use of Gene Gun for Genetic Immunotherapy: In Vitro and In Vivo Methods (pp. 223-240)
    Chang, Alfred E.; Tanigawa, Keishi; Turner, Joel G.; Chang, Edwin C.; Yu, Hua
14. Role of Cytokines in Pathology of Melanoma and Use of Biologic Response Modifiers in Melanoma (pp. 241-267)
    Clark, Joseph I.
15. Surgical Techniques for Treatment of Primary Cutaneous Melanoma (pp. 269-284)
    Robinson, June K.
16. Utility of Fine-Needle Aspiration Biopsy for Prospective Analysis of Patients Undergoing Therapy for Metastatic Melanoma (pp. 287-299)
    Riker, Adam I.
17. A Molecular Technique Useful in the Detection of Occult Metastases in Patients with Melanoma: RT-PCR Analysis of Sentinel Lymph Nodes and Peripheral Blood (pp. 301-320)
    Goydos, James S.; Reintgen, Douglas S.
18. Immunoscope Analysis of T-Lymphocytes Infiltrating Melanocytic Tumors Philippe Musette, Jos Even, Louis Dubertret, (pp. 321-337)
    Kourilsky, Philippe; Gachelin, Gabriel
19. T-Cell Receptor Clonotype Mapping Using Denaturing Gradient Gel Electrophoresis: Analysis of Clonal T-Cell Responses in Melanoma (pp. 339-351)
    Straten, Per thor; Becker, Jurgen C.; Zeuthen, Jesper; Guldberg, Per
20. Methods for Use of Peptide-MHC Tetramers in Tumor Immunology (pp. 353-362)
    Yee, Cassian; Lee, Peter P.
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