Library Science

Leading physician scientists and noted researchers describe step-by-step techniques for lung cancer diagnosis based on the molecular analysis of clinical samples. These experts review currently accepted treatments and outline a variety of novel therapies, including those based on gene therapy, immunotherapy, and chemoprevention, and show how these newly improved techniques can give a better appreciation of the prognosis associated with the particular mutation uncovered by the technique. These methods use a variety of molecular techniques, including the manipulation of gene expression and the alteration of immune status, to combat lung cancer.

Authors: Driscoll, Barbara

Table of Contents

1. Molecular and Genetic Aspects of Lung Cancer (pp. 03-26)
   Rom, William N.; Tchou-Wong, Kam-Meng
2. Molecular Alterations in Lung Cancer: Impact on Prognosis (pp. 29-38)
   Kijima, Takashi; Maulik, Gautam; Salgia, Ravi
3. Cellular Predictive Factors of Drug Resistance in Non-Small Cell Lung Carcinomas (pp. 39-52)
   Volm, Manfred; Koomagi, Reet; Rittgen, Werner
4. Clinical Implications of p53 Mutations in Lung Cancer (pp. 53-78)
   Campling, Barbara G.; El-Deiry, Wafik S.
5. An Epidemiologic and Clinicopathologic Overview of AIDS-Associated Pulmonary Kaposi???s Sarcoma (pp. 79-120)
   Aboulafia, David M.
6. Myeloperoxidase Promoter Region Polymorphism and Lung Cancer Risk (pp. 121-134)
   Wu, Xifeng; Schabath, Matthew B.; Spitz, Margaret R.
7. Clinical Utility of Tumor Markers in the Management of Non-Small Cell Lung Cancer (pp. 135-142)
   Niewoehner, Dennis E.; Rubins, Jeffrey B.
8. Detection of Chromosomal Aberrations in Lung Tissue and Peripheral Blood Lymphocytes Using Interphase Fluorescence In Situ Hybridization (FISH) (pp. 145-162)
   El-Zein, Randa A.; Abdel-Rahman, Sherif Z.
9. In Situ Analysis of Telomerase RNA Gene Expression as a Marker for Tumor Progression (pp. 163-176)
   Keith, W. Nicol
10. A High-Throughput Methodology for Identifying Molecular Targets Overexpressed in Lung Cancers (pp. 177-188)
    Wang, Tongtong; Reed, Steven G.
11. Expression Profi ling of Lung Cancer Based on Suppression Subtraction Hybridization (SSH) (pp. 189-208)
    Petersen, Simone; Petersen, Iver
12. Comparative Genomic Hybridization of Human Lung Cancer (pp. 209-238)
    Petersen, Iver
13. Sensitive Assays for Detection of Lung Cancer: Molecular Markers in Blood Samples (pp. 239-250)
    Fournier, Marcia V.; Martin, Katherine J.; Graner, Edgard; Pardee, Arthur B.
14. Fluorescent Microsatellite Analysis in Bronchial Lavage as a Potential Diagnostic Tool for Lung Cancer (pp. 251-262)
    Field, John K.; Liloglou, Triantafillos
15. Southern Blotting of Genomic DNA from Lung and Its Tumors: Application to Analysis of Allele Loss on Chromosome 11p15.5 (pp. 263-278)
    Pitterle, Diana M.; Bepler, Gerold
16. Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk (pp. 279-288)
    Wu, Xifeng; Yu, He; Makan, Nimisha; Spitz, Margaret R.
17. Comparative Multiplex PCR and Allele-Specifi c Expression Analysis in Human Lung Cancer: Tools to Facilitate Target Identifi cation (pp. 291-304)
    Heighway, Jim; Betticher, Daniel; Knapp, Teresa; Hoban, Paul
18. Detection of K-ras Point Mutations in Sputum from Patients with Adenocarcinoma of the Lung by Point-EXACCT (pp. 305-324)
    Somers, Veerle A. M. C.; Thunnissen, Frederick B. J. M.
19. Detection of K-ras and p53 Mutations by ??°Mutant-Enriched??² PCR-RFLP (pp. 325-334)
    Schuermann, Marcus
20. Detection of Small Cell Lung Cancer by RT-PCR for Neuropeptides, Neuropeptide Receptors, or a Splice Variant of the Neuron Restrictive Silencer Factor (pp. 335-352)
    Coulson, Judy M.; Ahmed, Samreen I.; Quinn, John P.; Woll, Penella J.
21. Utilization of Thyroid Transcription Factor-1 Immunostaining in the Diagnosis of Lung Tumors (pp. 355-368)
    Ordonez, Nelson G.
22. Molecular Biologic Substaging of Stage I NSCLC Through Immunohistochemistry Performed on Formalin-Fixed, Paraffi n-Embedded Tissue (pp. 369-388)
    Joshi, Mary-Beth Moore; D???Amico, Thomas A.; Harpole, David H.
23. A Sensitive Immunofl uorescence Assay for Detection of p53 Protein in the Sputum (pp. 389-396)
    Feng, Zumei; Tian, Defa; Goldman, Radoslav
24. SPR1: An Early Molecular Marker for Bronchial Carcinogenesis (pp. 397-404)
    Lau, Derick; Guo, Linlang; Chan, Andrew; Wu, Reen
25. Determination of Biological Parameters on Fine-Needle Aspirates from Non-Small Cell Lung Cancer (pp. 405-420)
    Bozzetti, Cecilia; Guazzi, Annamaria; Nizzoli, Rita; Naldi, Nadia; Franciosi, Vittorio; Cascinu, Stefano
26. Detection and Analysis of Lung Cancer Cells from Body Fluids Using a Rare Event Imaging System (pp. 423-430)
    Kraeft, Stine-Kathrein; Salgia, Ravi; Chen, Lan Bo
27. Reconstruction of Geno-Phenotypic Evolutionary equences from Intracellular Patterns of Molecular Abnormalities in Human Solid Tumors (pp. 431-450)
    Shackney, Stanley E.; Smith, Charles A.; Pollice, Agnese A.; Silverman, Jan F.
28. Surgical Treatment of Lung Cancer: Past And Present (pp. 453-488)
    Mountain, Clifton F.; Hermes, Kay E.
29. Recent Advances and Dilemmas in the Radiotherapeutic Management of Locally Advanced Non-Small Cell Lung Cancer (pp. 489-506)
    Movsas, Benjamin
30. Photodynamic Therapy in Lung Cancer: A Review (pp. 507-526)
    Ost, David
31. Gene Therapy for Lung Cancer: An Introduction (pp. 529-544)
    Haura, Eric B.; Sotomayor, Eduardo; Antonia, Scott J.
32. Identifying Obstacles to Viral Gene Therapy for Lung Cancer: Malignant Pleural Effusions as a Paradigm (pp. 545-560)
    Batra, Raj K.; Bernal, Raymond M.; Sharma, Sherven
33. Topical Gene Therapy for Pulmonary Diseases with PEI-DNA Aerosol Complexes (pp. 561-572)
    Gautam, Ajay; Waldrep, J. Clifford; Orson, Frank M.; Kinsey, Berma M.; Xu, Bo; Densmore, Charles L.
34. Targeted Delivery of Expression Plasmids to the Lung via Macroaggregated Polyethylenimine-Albumin Conjugates (pp. 573-590)
    Orson, Frank M.; Kinsey, Berma M.; Bhogal, Balbir S.; Song, Ling; Densmore, Charles L.; Barry, Michael A.
35. Preparation of Retroviral Vectors for Cell-Cycle-Targeted Gene Therapy of Lung Cancer (pp. 591-606)
    Claudio, Pier Paolo; Giordano, Antonio
36. Aerosol Gene Therapy for Metastatic Lung Cancer Using PEI-p53 Complexes (pp. 607-618)
    Gautam, Ajay; Waldrep, J. Clifford; Xu, Bo; Fung, Yuen-Kai; T???Ang, Anne; Densmore, Charles L.
37. Clinical Development of Antisense Oligonucleotides as Anti-Cancer Therapeutics (pp. 621-636)
    Chen, Helen X.
38. Antisense Oligonucleotides Targeting RIa Subunit of Protein Kinase A: In Vitro and In Vivo Anti-Tumor Activity and Pharmacokinetics (pp. 637-654)
    Zhang, Ruiwen; Wang, Hui
39. Use of Antisense Oligonucleotides for Therapy: Manipulation of Apoptosis Inhibitors for Destruction of Lung Cancer Cells (pp. 655-670)
    Leech, Sian H.; Olie, Robert A.; Zangemeister-Wittke, Uwe
40. Induction of Programmed Cell Death with an Antisense Bcl-2 Oligonucleotide (pp. 671-684)
    Koty, Patrick P.; Lei, Wendong; Levitt, Mark L.
41. Tumor Vaccination with Cytokine-Encapsulated Microspheres (pp. 687-696)
    Egilmez, Nejat K.; Jong, Yong S.; Mathiowitz, Edith; Bankert, Richard B.
42. Adoptive Immunotherapy (pp. 697-710)
    Kim, Julian A.; Shu, Suyu
43. Intratumoral Therapy with Cytokine Gene-Modified Dendritic Cells in Murine Lung Cancer Models (pp. 711-722)
    Sharma, Sherven; Yang, Seok Chul; Batra, Raj K.; Dubinett, Steven M.
44. Cyclooxygenase 2-Dependent Regulation of Antitumor Immunity in Lung Cancer (pp. 723-736)
    Sharma, Sherven; Huang, Min; Dohadwala, Mariam; Pold, Mehis; Batra, Raj K.; Dubinett, Steven M.
45. Chemoprevention of Lung Cancer (pp. 739-754)
    Witschi, Hanspeter
46. Assessing the Interaction of Particulate Delivery Systems with Lung Surfactant (pp. 755-770)
    Wiedmann, Timothy Scott
47. Chemopreventive Therapeutics: Inhalation Therapies for Lung Cancer and Bronchial Premalignancy (pp. 771-780)
    Haigentz, Missak; Perez-Soler, Roman

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