Library Science

Leading physician scientists and noted researchers review novel methods for determining the etiology of a variety of lung cancers and present readily reproducible techniques for examining the associated multitude of genetic abnormalities. The methods make it possible to detect these alterations at the cellular, DNA, and protein levels, to study the development of lung cancer in vitro and in vivo-either in situ or in the form of metastases, and to test targeted therapies with detailed model systems. An animal models section gives explicit instructions for setting up and testing these systems, which are rarely described in the literature.

Authors: Driscoll, Barbara

Table of Contents

1. Characteristic Genetic Alterations in Lung Cancer (pp. 03-28)
   Wistuba, Ignacio I.; Gazdar, Adi F.
2. Clinical and Biological Relevance of Recently Defi ned Categories of Pulmonary Neoplasia (pp. 31-42)
   Gabrielson, Edward
3. Molecular Epidemiology of Human Cancer Risk: Gene-Environment Interactions and p53 Mutation Spectrum in Human Lung Cancer (pp. 43-60)
   Vahakangas, Kirsi
4. Neuroendocrine Phenotype of Small Cell Lung Cancer (pp. 61-74)
   Coulson, Judy M.; Ocejo-Garcia, Marta; Woll, Penella J.
5. AIDS-Associated Pulmonary Cancers (pp. 75-86)
   Katariya, Kushagra; Thurer, Richard J.
6. Abrogation of the RB-p16 Tumor Suppressor Pathway in Human Lung Cancer (pp. 89-100)
   Geradts, Joseph
7. Sensitive Detection of Hypermethylated p16INK4a Alleles in Exfoliative Tissue Material (pp. 101-110)
   Schuermann, Marcus; Kersting, Michael
8. Role of Receptor Tyrosine Kinases in Lung Cancer (pp. 113-126)
   Maulik, Gautam; Kijima, Takashi; Salgia, Ravi
9. Relationship of EGFR Signal-Transduction Modulation by Tyrosine Kinase Inhibitors to Chemosensitivity and Programmed Cell Death in Lung Cancer Cell Lines (pp. 127-144)
   Lei, Wendong; Koty, Patrick P.; Levitt, Mark L.
10. Detection of the Transcripts and Proteins for the Transforming Growth Factor-?÷ Isoforms and Receptors in Mouse Lung Tumorigenesis Using In Situ Hybridization and Immunohistochemistry in Paraffi n-Embedded Tissue Sections (pp. 145-166)
    Jakowlew, Sonia B.; Mariano, Jennifer
11. Alterations in the Expression of Insulin-Like Growth Factors and Their Binding Proteins in Lung Cancer (pp. 167-186)
    Coleman, Carrie M.; Grimberg, Adda
12. Screening of Mutations in the ras Family of Oncogenes by Polymerase Chain Reaction-Based Ligase Chain Reaction (pp. 187-200)
    Martinez, Alfredo; Lehman, Teresa A.; Modali, Rama; Mulshine, James L.
13. Assays for Raf-1 Kinase Phosphorylation and Activity in Human Small Cell Lung Cancer Cells (pp. 201-210)
    Ravi, Rajani K.; Nelkin, Barry D.
14. y-Glutamylcysteine Synthetase in Lung Cancer: Effect on Cell Viability (pp. 211-222)
    Jarvinen, Kristiina; Soini, Ylermi; Kinnula, Vuokko L.
15. Localization of Cyclooxygenase-2 Protein Expression in Lung Cancer Specimens by Immunohistochemical Analysis (pp. 223-230)
    Wardlaw, Sarah A.; March, Thomas H.
16. Non-RI Protocols for L- myc Allelotyping and Deletion Mapping of Chromosome 1p in Primary Lung Cancers (pp. 231-240)
    Hiyama, Keiko; Mendoza, Ciro; Hiyama, Eiso
17. Intercellular Adhesion Molecules (ICAM-1, VCAM-1, and LFA-1) in Adenocarcinoma of Lung: Technical Aspects (pp. 243-250)
    Fraire, Armando E.; Woda, Bruce A.; Savas, Louis; Jiang, Zhong
18. MUC1 Expression in Lung Cancer (pp. 251-258)
    Szabo, Eva
19. Altered Surface Markers in Lung Cancer: Lack of Cell-Surface Fas/APO-1 Expression in Pulmonary Adenocarcinoma May Allow Escape from Immune Surveillance (pp. 259-266)
    Nambu, Yoshihiro; Beer, David G.
20. Prognostic Relevance of Angiogenic, Proliferative, and Apoptotic Factors in Lung Carcinomas: A Case Review (pp. 269-282)
    Volm, Manfred; Koomagi, Reet
21. Morphological Assessment of Apoptosis in Human Lung Cells (pp. 283-298)
    Dwyer-Nield, Lori D.; Dinsdale, David; Cohen, J. John; Squier, Margaret K. T.; Malkinson, Alvin M.
22. [D-Arg,6, D-Trp7,9, NmePhe8]-Substance P (6-11) Activates JNK and Induces Apoptosis in Small Cell Lung Cancer Cells via an Oxidant-Dependent Mechanism (pp. 299-308)
    MacKinnon, Alison; Sethi, Tariq
23. Isolation of Cells Entering Different Programmed Cell Death Pathways Using a Discontinuous Percoll Gradient (pp. 309-326)
    Koty, Patrick P.; Zhang, Haifan; Lei, Wendong; Levitt, Mark L.
24. Angiogenesis, Metastasis, and Lung Cancer: An Overview (pp. 329-348)
    Onn, Amir; Herbst, Roy S.
25. Matrix Metalloproteinase Expression in Lung Cancer (pp. 349-356)
    Lim, Melissa; Jablons, David M.
26. Vascular Endothelial Growth Factor Expression in Non-Small Cell Lung Cancer (pp. 357-374)
    O???Byrne, Kenneth J.; Goddard, Jonathan; Giatromanolaki, Alexandra; Koukourakis, Michael I.
27. Regulation of Angiostatin Mobilization by Tumor-Derived Matrix Metalloproteinase-2 (pp. 375-390)
    Moses, Marsha A.; O???Reilly, Michael S.
28. In Vitro and In Vivo Assays for the Proliferative and Vascular Permeabilization Activities of Vascular Endothelial Growth Factor (VEGF) and Its Receptor (pp. 391-398)
    Yano, Seiji; Herbst, Roy S.; Sone, Sabura
29. Detection of Telomerase Activity in Lung Cancer Tissues (pp. 401-412)
    Hiyama, Keiko; Hiyama, Eiso
30. Analysis of Alterations in a Base-Excision Repair Gene in Lung Cancer (pp. 413-438)
    Bhattacharyya, Nandan
31. Induction of Lung Cancer by Passive Smoking in an Animal Model System (pp. 441-456)
    Witschi, Hanspeter
32. Metastatic Orthotopic Mouse Models of Lung Ca (pp. 457-464)
    Hoffman, Robert M.
33. Lung-Specifi c Expression of Mutant p53 as Mouse Model for Lung Cancer (pp. 465-480)
    Tchou-Wong, Kam-Meng; Rom, William N.
34. Use of Nucleotide Excision Repair-Defi cient Mice as a Model For Chemically Induced Lung Cancer (pp. 481-492)
    Cheo, David L.; Friedberg, Errol C.
35. Nude Mouse Lung Metastases Models of Osteosarcoma and Ewing???s Sarcoma for Evaluating New Therapeutic Strategies (pp. 495-506)
    Jia, Shu-Fang; Zhou, Rong-Rong; Kleinerman, Eugenie S.
36. Tumor-Specifi c Metastasis to Lung Using Reporter Gene-Tagged Tumor Cells (pp. 507-524)
    Culp, Lloyd A.; Lin, Wen-Chang; Kleinman, Nanette; Holleran, Julianne L.; Miller, Carson J.
37. Cultures of Surgical Material from Lung Cancers: A Kinetic Approach (pp. 527-544)
    Baguley, Bruce C.; Marshall, Elaine S.; Christmas, Timothy I.
38. The Hollow Fiber Assay (pp. 545-566)
    Hall, Leslie-Ann M.; Krauthauser, Candice M.; Wexler, Roseanne S.; Slee, Andrew M.; Kerr, Janet S.

This entry was posted on Saturday, December 23rd, 2006 at 2:53 pm and is filed under BioLibrary, Library, Molecular Medicine. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.