Library Science

State-of-the-art review articles by leading experts summarize how to develop and employ the highly promising new DNA vaccines, what clinical results can be expected from their use, and what is known about how they work. Key topics range from vaccine design and construction to preparation and delivery methods, including the use of classical adjuvants, “genetic adjuvants,” and the immunostimulatory properties of DNA and selected oligonucleotide sequences. Several contributors provide strategic ideas on antigen engineering and describe the novel applications of DNA vaccine methodology that have recently emerged. Cutting-edge and comprehensive, DNA Vaccines: Methods and Protocols provides a snapshot of the methods and thinking from which the vaccines of tomorrow will evolve. Ed. Lowrie, Douglas B. ; Whalen, Robert

Table of Contents

1. Purification of Supercoiled Plasmid (pp. 1-10)
   Green, Anthony P.
2. Production of Plasmid DNA in Industrial Quantities According to cGMP Guidelines (pp. 11-22)
   Schorr, Joachim; Moritz, Peter; Schleef, Martin
3. Development and Characterization of Lyophilized DNA Vaccine Formulations (pp. 23-34)
   Shen, Nancy L.; Hartikka, Jukka; Horn, Nancy A.; Manthorpe, Marston; Marquet, Magda
4. Repeated Use of Qiagen Columns in Large-Scale Preparation of Plasmid DNA (pp. 35-36)
   Gregory, Derek; Tascon, Ricardo E.; Lowrie, Douglas B.
5. The Immunology of DNA Vaccines (pp. 37-64)
   Tuting, Thomas; Austyn, Jonathan; Storkus, Walter J.; Falo, Louis D.
6. Methodology Used in DNA-Based Prophylactic and Therapeutic Immunization Against Hepatitis B Virus in Chimpanzees (pp. 65-70)
   Prince, Alfred M.; Brotman, Betsy
7. Intramuscular and Intradermal Injection of DNA Vaccines in Mice and Primates (pp. 71-78)
   Davis, Heather L.
8. Veterinary DNA Vaccines (pp. 79-94)
   Hurk, Sylvia van Drunen Littel-van den; Braun, Ralph P.; Babiuk, Lorne A.
9. DNA-Based Immunization of Neonatal Mice (pp. 95-98)
   Millan, Cynthia L. Brazolot; Davis, Heather L.
10. Intramuscular Injection of DNA Vaccines in Fish (pp. 99-104)
    Heppell, Joel; Davis, Heather L.
11. Development of DNA Vaccines for Salmonid Fish (pp. 105-122)
    Anderson, Eric D.; Leong, Jo-Ann C.
12. CTL Analysis for Tumor Vaccines (pp. 123-132)
    Rosato, Antonio; Milan, Gabriella; Zambon, Annalisa; Zanovello, Paola; Collavo, Dino
13. The Use of Bone Marrow-Chimeric Mice in Determining the MHC Restriction of Epitope-Specific Cytotoxic T Lymphocytes (pp. 133-144)
    Iwasaki, Akiko; Barber, Brian H.
14. Immunostimulatory DNA Sequences: An Overview (pp. 145-168)
    Van Uden, John H.; Raz, Eyal
15. Immunostimulatory CpG Motifs and DNA Vaccines (pp. 169-172)
    Weeratna, Risini; Krieg, Arthur M.; Davis, Heather L.
16. In Vitro Assay of Immunostimulatory Activities of Plasmid Vectors (pp. 173-184)
    Reich, Charles F.; Pisetsky, David S.
17. Adjuvants for Plasmid DNA Vaccines (pp. 185-196)
    Norman, Jon; Hartikka, Jukka; Strauch, Pamela; Manthorpe, Marston
18. Cytokine and Costimulatory Factor-Encoding Plasmids as Adjuvants for DNA Vaccination (pp. 197-204)
    Okuda, Kenji; Kawamoto, Susumu; Fukushima, Jun
19. Optimization of DNA Vaccines Through the Use of Molecular Adjuvants (pp. 205-220)
    Kim, Jong J.; Weiner, David B.
20. Cytokine Fusion Constructs as DNA Vaccines Against Tumors (pp. 221-240)
    Maecker, Holden T.; Syrengelas, Athanasia; Levy, Ronald
21. The Use of Conventional Immunologic Adjuvants in DNA Vaccine Preparations (pp. 241-250)
    Sasaki, Shin; Okuda, Kenji
22. Genetic Adjuvants (pp. 251-260)
    Ertl, Hildegund C. J.; Pasquini, Susanna; He, Zhenning; Deng, Hongying; Showe, Louise; Giles-Davis, Wynetta; Wang, Yijie; O, InSug; Marston, Hilary; Blaszczyk-Thurin, Magdalena; Xiang, Zhiquan
23. DNA Immunization in Combination with the Immunostimulant Monophosphoryl Lipid A (pp. 261-266)
    Lodmell, Donald L.; Ray, Nancy B.; Ewalt, Larry C.
24. Controlled Plasmid Delivery and Gene Expression: Applications for Nucleic Acid-Based Vaccines (pp. 267-286)
    Mumper, Russell J.; Ledebur, Harry C.; Rolland, Alain P.; Tomlinson, Eric
25. Mucosal Immunization with DNA Vaccines (pp. 287-296)
    McCluskie, Michael J.; Davis, Heather L.
26. Preparations for Particle-Mediated Gene Transfer Using the Accell?? Gene Gun (pp. 297-304)
    Macklin, Michael D.; Drape, Robert J.; Swain, William F.
27. Entrapment of Plasmid DNA Vaccines into Liposomes by Dehydration/Rehydration (pp. 305-312)
    Gregoriadis, Gregory; McCormack, Brenda; Obrenovich, Mia; Perrie, Yvonne
28. DNA-Based Vaccination with Polycistronic Expression Plasmids (pp. 313-322)
    Schirmbeck, Reinhold; von Kampen, Jan; Metzger, Karin; Wild, Jens; Gruner, Beate; Schleef, Martin; Kroger, Andrea; Hauser, Hansjorg; Reimann, Jorg
29. A Nonviral Cytoplasmic T7 Autogene System and Its Applications in DNA Vaccination (pp. 323-334)
    Sturtz, Franck G.; Li, Yunsheng; Shulok, Janine; Snodgrass, H. Ralph; Chen, Xiao-zhuo
30. Immunization with Naked DNA Coexpressing Antigen and Cytokine via IRES (pp. 335-344)
    Heinrich, Jochen; Strack, Bettina; Nawrath, Michael; Pavlovic, Jovan; Moelling, Karin
31. Genetic Subunit Vaccines: A Novel Approach for Genetic Immunization (pp. 345-354)
    Ciernik, I. Frank; Carbone, David P.
32. Antigen Engineering in DNA Immunization (pp. 355-374)
    Lu, Shan; Manning, Steve; Arthos, James
33. Genetic Vaccination Targeting T-Cell Receptors (pp. 375-396)
    Godillot, Alexis P.; Fang, Qiong; Higgins, Terry; Pachuk, Catherine; Boyer, Jean; Weiner, David B.; Lessin, Stuart; Williams, William V.
34. Immunity to T-Cell Receptor: Suppressive Vaccination with DNA Encoding a Variable Region Gene of the T-Cell Receptor (pp. 397-404)
    Waisman, Ari
35. DNA Fusion Vaccines Against B-Cell Tumors (pp. 405-424)
    Zhu, Delin; Spellerberg, Myfanwy B.; King, Catherine A.; Rice, Jason; Thompsett, Andrew R.; Stevenson, Freda K.
36. DNA-Based Vaccination Primes Tumor-Rejecting T-Cell Responses (pp. 425-438)
    Bohm, Waltraud; Schleef, Martin; Thoma, Stefan; Schirmbeck, Reinhold; Reimann, Jorg
37. Development of Female Contraceptive Vaccine Through DNA Inoculation of Human Chorionic Gonadotropin Beta Subunit (hCG?÷) (pp. 439-450)
    Zhang, Fu-chun; Wang, Ni; Liu, Dong-mei; Jian, Youli; Chen, You-zhen; Shen, Xiao-zhou; Cao, Yong-qing; Wang, Bin
38. Genetic Immunization for Allergy Immunotherapy (pp. 451-472)
    Roman, Mark; Tighe, Helen; Spiegelberg, Hans L.; Broide, David; Raz, Eyal
39. Preclinical Safety of DNA Vaccines: A Method to Analyze the Distribution of Plasmid DNA in Animal Models (pp. 473-488)
    Ciccarelli, Richard B.; Pachuk, Catherine J.; Samuel, Manoj; Winter, Laurie A.; Satishchandran, C.
40. DNA Vaccination: Tolerance and Autoimmunity (pp. 489-498)
    Mor, Gil; Eliza, Mariel
41. Assuring the Quality, Safety, and Efficacy of DNA Vaccines (pp. 499-508)
    Robertson, James S.; Griffiths, Elwyn

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