Library Science

A collection of key cytogenetic and FISH techniques used by modern clinical laboratories in the genetic analysis of human malignancies. The book’s practical advice and methods are suitable for use at every level of expertise, including fully established laboratories, but with a sympathetic bias towards anyone considering setting up a new cytogenetics service. Here the reader will find not only elementary tutorials on the fundamentals of human karyotypes and chromosome analysis, but also detailed discussions on how laboratories may optimally upgrade their repertoire of capabilities to include such newer complementary techniques as CGH, FISH, and M-FISH.  Ed. Swansbury, John

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Table of Contents

1. Introduction (pp. 001-008)
   Swansbury, John
2. Cytogenetic Studies in Hematologic Malignancies: An Overview (pp. 009-022)
   Swansbury, John
3. The Myeloid Disorders: Background (pp. 023-042)
   Swansbury, John
4. Cytogenetic Techniques for Myeloid Disorders (pp. 043-058)
   Swansbury, John
5. Acute Lymphoblastic Leukemia: Background (pp. 059-072)
   Swansbury, John
6. Conventional Cytogenetic Techniques in the Diagnosis of Childhood Acute Lymphoblastic Leukemia (pp. 073-082)
   Raimondi, Susana C.; Mathew, Susan
7. Chromosome Preparations from Bone Marrow in Acute Lymphoblastic Leukemia: Cytogenetic Techniques (pp. 083-092)
   Watmore, Ann
8. Lymphoid Disorders Other than Common Acute Lymphoblastic Leukemia: Background (pp. 093-110)
   Swansbury, John
9. Other Lymphoid Malignancies: Cytogenetic Techniques (pp. 111-124)
   Swansbury, John
10. Cytogenetic and Genetic Studies in Solid Tumors Background (pp. 125-134)
    Swansbury, John
11. Human Solid Tumors: Cytogenetic Techniques (pp. 135-150)
    Polito, Pietro; Cin, Paola Dal; Debiec-Rychter, Maria; Hagemeijer, Anne
12. Analysis and Interpretation of Cytogenetic Findings in Malignancy (pp. 151-172)
    Swansbury, John
13. Cytogenetic Studies Using FISH: Background (pp. 173-192)
    Min, Toon; Swansbury, John
14. FISH Techniques (pp. 193-212)
    Min, Toon
15. FISH, CGH, and SKY in the Diagnosis of Childhood Acute Lymphoblastic Leukemia (pp. 213-234)
    Mathew, Susan; Raimondi, Susana C.
16. Solving Problems in Multiplex FISH (pp. 235-244)
    Strefford, Jon C.
17. Some Difficult Choices in Cytogenetics (pp. 245-258)
    Swansbury, John
18. Introduction to the Analysis of the Human G-Banded Karyotype (pp. 259-270)
    Swansbury, John

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