Library Science

This collection of review articles highlights the latest development of antithrombotics and provides proven experimental methods for the further development of new and improved anticoagulants. Among the cutting-edge developments reviewed are the novel usage of low molecular weight heparins, such antithrombin agents as the hirudin, and such antiplatelet drugs as the GPIIb/IIIa inhibitors and ADP receptor antagonists. Additional innovations discussed include aspirin and clopidogrel, the expanded use of polytherapeutic approaches, antiproteases (factors IIa, Xa, and VIIa), tissue factor targeting, platelet receptor targeting, and antithrombin III modulation.

Authors: Mousa, Shaker A.

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Table of Contents

1. Highlights of Latest Advances in Antithrombotics (pp. 1-8)
   Mousa, Shaker A.
2. Antiplatelet, Anticoagulant, and Thrombolytic Drug Interactions (pp. 9-20)
   Iqbal, Omer; Mousa, Shaker A.
3. Evaluation of Platelet Antagonists in In Vitro Flow Models of Thrombosis (pp. 21-34)
   McCarty, Owen J. T.; Abulencia, James P.; Mousa, Shaker A.; Konstantopoulos, Konstantinos
4. Heparin and Low Molecular Weight Heparin in Thrombosis, Cancer, and Inflammatory Diseases (pp. 35-48)
   Mousa, Shaker A.
5. Are Low Molecular Weight Heparins the Same? (pp. 49-60)
   Mousa, Shaker A.
6. Antithrombotic Drugs for the Treatment of Heparin-Induced Thrombocytopenia (pp. 61-82)
   Jeske, Walter P.; M.Walenga, Jeanine
7. Laboratory Methods for Heparin-Induced Thrombocytopenia (pp. 83-94)
   Prechel, Margaret; Jeske, Walter P.; Walenga, Jeanine M.
8. Factor Xa Inhibitors (pp. 95-118)
   M.Walenga, Jeanine; Jeske, Walter P.; Hoppensteadt, Debra; Fareed, Jawed
9. Tissue Factor/VIIa in Thrombosis and Cancer (pp. 119-132)
   Mousa, Shaker A.
10. Tissue Factor Pathway Inhibitor in Thrombosis and Beyond (pp. 133-156)
    Mousa, Shaker A.; Fareed, Jawed; Iqbal, Omer; Kaiser, Brigitte
11. Cell Adhesion Molecules: Potential Therapeutic and Diagnostic Implications (pp. 157-174)
    Mousa, Shaker A.
12. Development and Applications of Animal Models of Thrombosis (pp. 175-220)
    Shebuski, Ronald J.; Bush, Larry R.; Gagnon, Alison; Chi, Liguo; Leadley, Robert J.
13. A Survey of Venous Thrombosis Models (pp. 221-238)
    Jeske, Walter P.; Iqbal, Omer; Fareed, Jawed; Kaiser, Brigitte
14. Arixtra (Fondaparinux Sodium) (pp. 239-246)
    Mousa, Shaker A.
15. Oral Thrombin Inhibitor Ximelagatran (pp. 247-252)
    Mousa, Shaker A.
16. Pharmacogenomics and Coagulation Disorders (pp. 253-266)
    Iqbal, Omer
17. Guidelines for Diagnosis and Treatment of Deep Venous Thrombosis and Pulmonary Embolism (pp. 267-292)
    Abdel-Razeq, Hikmat; Qari, Mohamad; Kristensen, Jorgen; Alizeidah, Hussein; Al-Sayegh, Faisal; Marashi, Mahmoud; Alzeer, Abdulaziz; Al-Amoudi, Omar; Qutub, Hatem; Al-Humiadi, Abdel-Aziz; Husted, Steen; Mousa, Shaker A.

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